Abstract:
:Mutations in over 70 genes now define biological pathways leading to epilepsy, an episodic dysrhythmia of the cerebral cortex marked by abnormal network synchronization. Some of the inherited errors destabilize neuronal signaling by inflicting primary disorders of membrane excitability and synaptic transmission, whereas others do so indirectly by perturbing critical control points that balance the developmental assembly of inhibitory and excitatory circuits. The genetic diversity is now sufficient to discern short- and long-range functional convergence of epileptogenic molecular pathways, reducing the broad spectrum of primary molecular defects to a few common processes regulating cortical synchronization. Synaptic inhibition appears to be the most frequent target; however, each gene mutation retains unique phenotypic features. This review selects exemplary members of several gene families to illustrate principal categories of the disease and trace the biological pathways to epileptogenesis in the developing brain.
journal_name
Annu Rev Neuroscijournal_title
Annual review of neuroscienceauthors
Noebels JLdoi
10.1146/annurev.neuro.26.010302.081210keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
599-625eissn
0147-006Xissn
1545-4126journal_volume
26pub_type
杂志文章,评审abstract::According to embodied cognition theories, higher cognitive abilities depend on the reenactment of sensory and motor representations. In the first part of this review, we critically analyze the central claims of embodied theories and argue that the existing behavioral and neuroimaging data do not allow investigators to...
journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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journal_title:Annual review of neuroscience
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pub_type: 历史文章,杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2018-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2018-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2019-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2019-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
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更新日期:2013-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2019-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2013-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章
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更新日期:2020-07-08 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00