Synaptic Plasticity Forms and Functions.

Abstract:

:Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long been considered an important component of learning and memory. Computational and engineering work corroborate the power of learning through the directed adjustment of connection weights. Here we review the fundamental elements of four broadly categorized forms of synaptic plasticity and discuss their functional capabilities and limitations. Although standard, correlation-based, Hebbian synaptic plasticity has been the primary focus of neuroscientists for decades, it is inherently limited. Three-factor plasticity rules supplement Hebbian forms with neuromodulation and eligibility traces, while true supervised types go even further by adding objectives and instructive signals. Finally, a recently discovered hippocampal form of synaptic plasticity combines the above elements, while leaving behind the primary Hebbian requirement. We suggest that the effort to determine the neural basis of adaptive behavior could benefit from renewed experimental and theoretical investigation of more powerful directed types of synaptic plasticity.

journal_name

Annu Rev Neurosci

authors

Magee JC,Grienberger C

doi

10.1146/annurev-neuro-090919-022842

subject

Has Abstract

pub_date

2020-07-08 00:00:00

pages

95-117

eissn

0147-006X

issn

1545-4126

journal_volume

43

pub_type

杂志文章
  • The neuropsychopharmacology of fronto-executive function: monoaminergic modulation.

    abstract::We review the modulatory effects of the catecholamine neurotransmitters noradrenaline and dopamine on prefrontal cortical function. The effects of pharmacologic manipulations of these systems, sometimes in comparison with the indoleamine serotonin (5-HT), on performance on a variety of tasks that tap working memory, a...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.051508.135535

    authors: Robbins TW,Arnsten AF

    更新日期:2009-01-01 00:00:00

  • Genes Involved in the Development and Physiology of Both the Peripheral and Central Auditory Systems.

    abstract::The genetic approach, based on the study of inherited forms of deafness, has proven to be particularly effective for deciphering the molecular mechanisms underlying the development of the peripheral auditory system, the cochlea and its afferent auditory neurons, and how this system extracts the physical parameters of ...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-070918-050428

    authors: Michalski N,Petit C

    更新日期:2019-07-08 00:00:00

  • Parallel pathways for spectral coding in primate retina.

    abstract::The primate retina is an exciting focus in neuroscience, where recent data from molecular genetics, adaptive optics, anatomy, and physiology, together with measures of human visual performance, are converging to provide new insights into the retinal origins of color vision. Trichromatic color vision begins when the im...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.23.1.743

    authors: Dacey DM

    更新日期:2000-01-01 00:00:00

  • Long-term depression in hippocampus.

    abstract::Long-term depression (LTD) is a lasting decrease in synaptic effectiveness that follows some types of electrical stimulation in the hippocampus. Two broad types of LTD may be distinguished. Heterosynaptic LTD can occur at synapses that are inactive, normally during high-frequency stimulation of a converging synaptic i...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ne.19.030196.002253

    authors: Bear MF,Abraham WC

    更新日期:1996-01-01 00:00:00

  • The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.

    abstract::Rhythmicity is a universal timing mechanism in the brain, and the rhythmogenic mechanisms are generally dynamic. This is illustrated for the neuronal control of breathing, a behavior that occurs as a one-, two-, or three-phase rhythm. Each breath is assembled stochastically, and increasing evidence suggests that each ...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-080317-061756

    authors: Ramirez JM,Baertsch NA

    更新日期:2018-07-08 00:00:00

  • Active and passive immunotherapy for neurodegenerative disorders.

    abstract::Immunotherapeutic strategies to combat neurodegenerative disorders have galvanized the scientific community since the first dramatic successes in mouse models recreating aspects of Alzheimer disease (AD) were reported. However, initial human trials of active amyloid-beta (Abeta) vaccination were halted early because o...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.31.060407.125529

    authors: Brody DL,Holtzman DM

    更新日期:2008-01-01 00:00:00

  • The cell biology of the blood-brain barrier.

    abstract::The blood-brain barrier (BBB) is formed by brain capillary endothelial cells (ECs). In the late embryonic and early postnatal period, these cells respond to inducing factors found in the brain environment by adopting a set of defined characteristics, including high-electrical-resistance tight junctions. Although the f...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.22.1.11

    authors: Rubin LL,Staddon JM

    更新日期:1999-01-01 00:00:00

  • From atomic structures to neuronal functions of g protein-coupled receptors.

    abstract::G protein-coupled receptors (GPCRs) are essential mediators of signal transduction, neurotransmission, ion channel regulation, and other cellular events. GPCRs are activated by diverse stimuli, including light, enzymatic processing of their N-termini, and binding of proteins, peptides, or small molecules such as neuro...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-062012-170313

    authors: Palczewski K,Orban T

    更新日期:2013-07-08 00:00:00

  • Chemogenetic tools to interrogate brain functions.

    abstract::Elucidating the roles of neuronal cell types for physiology and behavior is essential for understanding brain functions. Perturbation of neuron electrical activity can be used to probe the causal relationship between neuronal cell types and behavior. New genetically encoded neuron perturbation tools have been develope...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-071013-014048

    authors: Sternson SM,Roth BL

    更新日期:2014-01-01 00:00:00

  • Neural network dynamics.

    abstract::Neural network modeling is often concerned with stimulus-driven responses, but most of the activity in the brain is internally generated. Here, we review network models of internally generated activity, focusing on three types of network dynamics: (a) sustained responses to transient stimuli, which provide a model of ...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.28.061604.135637

    authors: Vogels TP,Rajan K,Abbott LF

    更新日期:2005-01-01 00:00:00

  • Neuropeptides in identified Aplysia neurons.

    abstract::Extensive electrophysiological experiments on Aplysia neurons have resulted in an understanding of simple behaviors in terms of the activities of a single identified neurons. Beginning with the work of Kupfermann & Kandel, neuropeptides in Aplysia have become increasingly implicated as chemical agents that control or ...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ne.08.030185.002243

    authors: Kaldany RR,Nambu JR,Scheller RH

    更新日期:1985-01-01 00:00:00

  • Neuron-Glia Signaling in Synapse Elimination.

    abstract::Maturation of neuronal circuits requires selective elimination of synaptic connections. Although neuron-intrinsic mechanisms are important in this process, it is increasingly recognized that glial cells also play a critical role. Without proper functioning of these cells, the number, morphology, and function of synapt...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-070918-050306

    authors: Wilton DK,Dissing-Olesen L,Stevens B

    更新日期:2019-07-08 00:00:00

  • The mirror-neuron system.

    abstract::A category of stimuli of great importance for primates, humans in particular, is that formed by actions done by other individuals. If we want to survive, we must understand the actions of others. Furthermore, without action understanding, social organization is impossible. In the case of humans, there is another facul...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.27.070203.144230

    authors: Rizzolatti G,Craighero L

    更新日期:2004-01-01 00:00:00

  • Prion diseases of humans and animals: their causes and molecular basis.

    abstract::Prion diseases are transmissible neurodegenerative conditions that include Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE) and scrapie in animals. Prions appear to be composed principally or entirely of abnormal isoforms of a host-encoded glycoprotein, prion protein. Prion propagat...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.24.1.519

    authors: Collinge J

    更新日期:2001-01-01 00:00:00

  • 3D Brain Organoids: Studying Brain Development and Disease Outside the Embryo.

    abstract::Scientists have been fascinated by the human brain for centuries, yet knowledge of the cellular and molecular events that build the human brain during embryogenesis and of how abnormalities in this process lead to neurological disease remains very superficial. In particular, the lack of experimental models for a proce...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章

    doi:10.1146/annurev-neuro-070918-050154

    authors: Velasco S,Paulsen B,Arlotta P

    更新日期:2020-07-08 00:00:00

  • Deep brain stimulation for psychiatric disorders.

    abstract::Medications, psychotherapy, and other treatments are effective for many patients with psychiatric disorders. However, with currently available interventions, a substantial number of patients experience incomplete resolution of symptoms, and relapse rates are high. In the search for better treatments, increasing intere...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-061010-113638

    authors: Holtzheimer PE,Mayberg HS

    更新日期:2011-01-01 00:00:00

  • Quantitative genetics and mouse behavior.

    abstract::Quantitative differences are observed for most complex behavioral and pharmacological traits within any population. Both environmental and genetic influences regulate such individual differences. The mouse has proven to be a superb model in which to investigate the genetic basis for quantitative differences in complex...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.24.1.845

    authors: Wehner JM,Radcliffe RA,Bowers BJ

    更新日期:2001-01-01 00:00:00

  • Zinc and brain injury.

    abstract::Zinc is an essential catalytic or structural element of many proteins, and a signaling messenger that is released by neural activity at many central excitatory synapses. Growing evidence suggests that zinc may also be a key mediator and modulator of the neuronal death associated with transient global ischemia and sust...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.21.1.347

    authors: Choi DW,Koh JY

    更新日期:1998-01-01 00:00:00

  • Astrocytes and Behavior.

    abstract::Animal behavior was classically considered to be determined exclusively by neuronal activity, whereas surrounding glial cells such as astrocytes played only supportive roles. However, astrocytes are as numerous as neurons in the mammalian brain, and current findings indicate a chemically based dialog between astrocyte...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章

    doi:10.1146/annurev-neuro-101920-112225

    authors: Kofuji P,Araque A

    更新日期:2021-01-06 00:00:00

  • Noncanonical Wnt signaling and neural polarity.

    abstract::The Wnt signaling pathway regulates multiple events in development and disease in both vertebrates and invertebrates. Recently, the noncanonical Wnt signaling cascades, those that do not signal through beta-catenin, have gained prominence for their role in the regulation of cellular polarity. It is not surprising that...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.29.051605.112933

    authors: Montcouquiol M,Crenshaw EB 3rd,Kelley MW

    更新日期:2006-01-01 00:00:00

  • Unified Classification of Molecular, Network, and Endocrine Features of Hypothalamic Neurons.

    abstract::Peripheral endocrine output relies on either direct or feed-forward multi-order command from the hypothalamus. Efficient coding of endocrine responses is made possible by the many neuronal cell types that coexist in intercalated hypothalamic nuclei and communicate through extensive synaptic connectivity. Although gene...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-070918-050414

    authors: Romanov RA,Alpár A,Hökfelt T,Harkany T

    更新日期:2019-07-08 00:00:00

  • Noncoding RNAs in the mammalian central nervous system.

    abstract::The central nervous system (CNS) is arguably one of the most complex systems in the universe. To understand the CNS, scientists have investigated a variety of molecules, including proteins, lipids, and various small molecules. However, one large class of molecules, noncoding RNAs (ncRNAs), has been relatively unexplor...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.29.051605.112839

    authors: Cao X,Yeo G,Muotri AR,Kuwabara T,Gage FH

    更新日期:2006-01-01 00:00:00

  • The biology of epilepsy genes.

    abstract::Mutations in over 70 genes now define biological pathways leading to epilepsy, an episodic dysrhythmia of the cerebral cortex marked by abnormal network synchronization. Some of the inherited errors destabilize neuronal signaling by inflicting primary disorders of membrane excitability and synaptic transmission, where...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.26.010302.081210

    authors: Noebels JL

    更新日期:2003-01-01 00:00:00

  • The role of vesicular transport proteins in synaptic transmission and neural degeneration.

    abstract::Classical neurotransmitters are synthesized in the cytoplasm, so they require transport into secretory vesicles for regulated exocytotic release. Previous work has identified distinct vesicular transport activities for the different classical transmitters, and all depend on the H+-electrochemical gradient across the v...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.neuro.20.1.125

    authors: Liu Y,Edwards RH

    更新日期:1997-01-01 00:00:00

  • Structure of the adrenergic and related receptors.

    abstract::The isolation and sequencing of a number of G protein-coupled receptors has now provided extensive primary structure information for this family of homologous proteins. The diverse nature of these receptors suggests that the family of proteins may grow to include receptors for many neurotransmitters and perhaps many p...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.ne.12.030189.000435

    authors: O'Dowd BF,Lefkowitz RJ,Caron MG

    更新日期:1989-01-01 00:00:00

  • Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics.

    abstract::Ten years of remarkable progress in understanding the fundamental biochemistry of Alzheimer's disease have been followed by ten years of remarkable and increasing clinical insight into the natural progression of the disorder. The concept of a long, intermediary, prodromal phase between the first appearance of amyloid ...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-070815-014015

    authors: Sala Frigerio C,De Strooper B

    更新日期:2016-07-08 00:00:00

  • Muscarinic signaling in the brain.

    abstract::Muscarinic signaling affects attention, action selection, learning, and memory through multiple signaling cascades, which act at different timescales and which alter ion channels in cell type-specific manners. The effects of muscarinic signaling differ between cortical layers and between brain areas. Muscarinic signal...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-062012-170433

    authors: Thiele A

    更新日期:2013-07-08 00:00:00

  • Meta-analysis in human neuroimaging: computational modeling of large-scale databases.

    abstract::Spatial normalization--applying standardized coordinates as anatomical addresses within a reference space--was introduced to human neuroimaging research nearly 30 years ago. Over these three decades, an impressive series of methodological advances have adopted, extended, and popularized this standard. Collectively, th...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,meta分析

    doi:10.1146/annurev-neuro-062012-170320

    authors: Fox PT,Lancaster JL,Laird AR,Eickhoff SB

    更新日期:2014-01-01 00:00:00

  • Magnetic Strategies for Nervous System Control.

    abstract::Magnetic fields pass through tissue undiminished and without producing harmful effects, motivating their use as a wireless, minimally invasive means to control neural activity. Here, we review mechanisms and techniques coupling magnetic fields to changes in electrochemical potentials across neuronal membranes. Biologi...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-070918-050241

    authors: Christiansen MG,Senko AW,Anikeeva P

    更新日期:2019-07-08 00:00:00

  • From Cajal to Connectome and Beyond.

    abstract::One goal of systems neuroscience is a structure-function model of nervous system organization that would allow mechanistic linking of mind, brain, and behavior. A necessary but not sufficient foundation is a connectome, a complete matrix of structural connections between the nodes of a nervous system. Connections betw...

    journal_title:Annual review of neuroscience

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-neuro-071714-033954

    authors: Swanson LW,Lichtman JW

    更新日期:2016-07-08 00:00:00