Abstract:
:G protein-coupled receptors (GPCRs) are essential mediators of signal transduction, neurotransmission, ion channel regulation, and other cellular events. GPCRs are activated by diverse stimuli, including light, enzymatic processing of their N-termini, and binding of proteins, peptides, or small molecules such as neurotransmitters. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Moreover, modern genetic technology has helped identify a rich array of mono- and multigenic defects in humans and animal models that connect such receptor dysfunction with disease affecting neuronal function. The visual system is especially suited to investigate GPCR structure and function because advanced imaging techniques permit structural studies of photoreceptor neurons at both macro and molecular levels that, together with biochemical and physiological assessment in animal models, provide a more complete understanding of GPCR signaling.
journal_name
Annu Rev Neuroscijournal_title
Annual review of neuroscienceauthors
Palczewski K,Orban Tdoi
10.1146/annurev-neuro-062012-170313subject
Has Abstractpub_date
2013-07-08 00:00:00pages
139-64eissn
0147-006Xissn
1545-4126journal_volume
36pub_type
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Annual review of neuroscience
pub_type: 杂志文章,评审
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
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journal_title:Annual review of neuroscience
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