Noncoding RNAs in the mammalian central nervous system.

Abstract:

:The central nervous system (CNS) is arguably one of the most complex systems in the universe. To understand the CNS, scientists have investigated a variety of molecules, including proteins, lipids, and various small molecules. However, one large class of molecules, noncoding RNAs (ncRNAs), has been relatively unexplored. ncRNAs function directly as structural, catalytic, or regulatory molecules rather than serving as templates for protein synthesis. The increasing variety of ncRNAs being identified in the CNS suggests a strong connection between the biogenesis, dynamics of action, and combinatorial regulatory potential of ncRNAs and the complexity of the CNS. In this review, we give an overview of the diversity and abundance of ncRNAs before delving into specific examples that illustrate their importance in the CNS. In particular, we cover recent evidence for the roles of microRNAs, small nucleolar RNAs, retrotransposons, the NRSE small modulatory RNA, and BC1/BC200 in the CNS. Finally, we speculate why ncRNAs are well adapted to improving organism-environment interactions.

journal_name

Annu Rev Neurosci

authors

Cao X,Yeo G,Muotri AR,Kuwabara T,Gage FH

doi

10.1146/annurev.neuro.29.051605.112839

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

77-103

eissn

0147-006X

issn

1545-4126

journal_volume

29

pub_type

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