Involvement of decreased myo-inositol transport in lipopolysaccharide-induced depression of phosphoinositide hydrolysis in vascular smooth muscle.

Abstract:

:The mechanism underlying lipopolysaccharide (LPS)-induced depression of phosphoinositide (PI) hydrolysis was investigated using rat aortas. In LPS-pretreated aortas, the 5-hydroxytryptamine-stimulated accumulation of inositol monophosphate and incorporation of exogenous myo-inositol into PIs were significantly less than those in control aortas. Both sodium-myo-inositol cotransporter (SMIT) and phosphatidylinositol transfer protein (PITP) genes were constituently expressed in rat aortas. The mRNA level of SMIT was remarkably lower in LPS-pretreated aortas, while that of PITP mRNA was not affected by LPS. These results suggest that LPS-induced depression of SMIT expression is involved in inhibition of agonist-stimulated PI hydrolysis by LPS.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Sotoda Y,Negoro M,Wakabayashi I

doi

10.1016/s0014-5793(02)02747-3

keywords:

subject

Has Abstract

pub_date

2002-05-22 00:00:00

pages

227-30

issue

1-3

eissn

0014-5793

issn

1873-3468

pii

S0014579302027473

journal_volume

519

pub_type

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