Abstract:
:Despite significant advances in the management of trauma victims, traumatic injury with the ensuing sepsis and multiple organ failure remains the leading cause of death between the ages of 18 and 44 in the USA. Recently, interest in the clinically and experimentally observed gender dimorphic response to traumatic injury has led to the possibility of modulating cell and organ functions following trauma and hemorrhagic shock by the administration of sex steroids. Here, we review the effects of the adrenal steroid dehydroepiandrosterone (DHEA), a precursor of sex steroid synthesis, on organ and immune functions following trauma-hemorrhage, and its potential as a novel therapy for improving the depressed cell and organ functions in trauma patients.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Jarrar D,Kuebler JF,Wang P,Bland KI,Chaudry IHdoi
10.1016/s1471-4914(01)01917-7keywords:
subject
Has Abstractpub_date
2001-02-01 00:00:00pages
81-5issue
2eissn
1471-4914issn
1471-499Xpii
S1471-4914(01)01917-7journal_volume
7pub_type
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