Abstract：
:Mounting in vitro and in vivo data suggest that the endocannabinoids anandamide and 2-arachidonoyl glycerol, as well as some plant and synthetic cannabinoids, have neuroprotective effects following brain injury. Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission and reduce the production of tumour necrosis factor-alpha and reactive oxygen intermediates, which are factors in causing neuronal damage. The formation of the endocannabinoids anandamide and 2-arachidonoyl glycerol is strongly enhanced after brain injury, and there is evidence that these compounds reduce the secondary damage incurred. Some plant and synthetic cannabinoids, which do not bind to the cannabinoid receptors, have also been shown to be neuroprotective, possibly through their direct effect on the excitatory glutamate system and/or as antioxidants.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Mechoulam R,Panikashvili D,Shohami Edoi
10.1016/s1471-4914(02)02276-1keywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
58-61issue
2eissn
1471-4914issn
1471-499Xpii
S1471491402022761journal_volume
8pub_type
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