Abstract:
:Many organs throughout the body maintain epithelial homeostasis by employing a mucosal barrier which acts as a lubricant and helps to preserve a near-sterile epithelium. Goblet cells are largely responsible for secreting components of this mucosal barrier and represent a major cellular component of the innate defense system. In this review we summarize what is known about the signaling pathways that control goblet cell differentiation in the intestine, the lung, and the ocular surface, and we discuss a novel functional role for goblet cells in mucosal epithelial immunology. We highlight the cell type-specificity of the circuitry regulating goblet cell differentiation and shed light on how changes to these pathways lead to altered goblet cell function, a prominent feature of mucosa-associated diseases.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
McCauley HA,Guasch Gdoi
10.1016/j.molmed.2015.06.003subject
Has Abstractpub_date
2015-08-01 00:00:00pages
492-503issue
8eissn
1471-4914issn
1471-499Xpii
S1471-4914(15)00120-3journal_volume
21pub_type
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