Abstract：
:Innovative sequencing techniques now allow the routine access of whole genomes of pathogens, generating vast amounts of data. Phylogenetic trees are a common method for synthesizing this information. Unfortunately, these trees are often seen only as a visual support to guide researchers, thus neglecting the value of employing phylogenetic techniques to perform hypothesis testing on clinical questions. These include investigating how a pathogen spreads within a patient, or whether the infection severity (often measured by virus load) is controlled by viral genetics. Advances in methodology mean the time is ripe for combining phylogenies with clinical data to better understand and fight infectious diseases.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Hartfield M,Murall CL,Alizon Sdoi
10.1016/j.molmed.2014.04.002subject
Has Abstractpub_date
2014-07-01 00:00:00pages
394-404issue
7eissn
1471-4914issn
1471-499Xpii
S1471-4914(14)00063-Xjournal_volume
20pub_type
杂志文章,评审abstract：:Ten percent of inherited diseases are caused by premature termination codon (PTC) mutations that lead to degradation of the mRNA template and to the production of a non-functional, truncated polypeptide. In addition, many acquired mutations in cancer introduce similar PTCs. In 1999, proof-of-concept for treating these...
journal_title：Trends in molecular medicine
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doi：10.1016/j.molmed.2012.09.008
更新日期：2012-11-01 00:00:00
abstract：:Invariant natural killer T (iNKT) cells are innate lymphocytes with unique specificity for glycolipid antigens and remarkable immunomodulatory properties. The role of costimulatory interactions in iNKT cell responses has recently come under scrutiny. Although iNKT cells and their prototype glycolipid agonist α-galacto...
journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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更新日期：2011-06-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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更新日期：2012-12-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
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更新日期：2014-08-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2008-08-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2014.04.001
更新日期：2014-09-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2003-12-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2011-12-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2016-11-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章
doi：10.1016/j.molmed.2014.07.002
更新日期：2014-10-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2020-03-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2020.01.007
更新日期：2020-04-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2008.05.002
更新日期：2008-07-01 00:00:00
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 评论,信件
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更新日期：2015-05-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章
doi：10.1016/j.molmed.2010.10.008
更新日期：2011-02-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 杂志文章
doi：10.1016/j.molmed.2003.09.008
更新日期：2003-11-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2002-01-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2001-10-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章
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更新日期：2004-02-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2017.11.003
更新日期：2018-01-01 00:00:00
