Abstract：
:Aging is characterized by irreversible loss of physiological integrity, often accompanied by an organism's loss of function and increased vulnerability to death. Defects in the mechanisms preserving cellular homeostasis over time may give rise to accelerated aging. Somatic cell reprogramming of aged cells can be associated with rejuvenation, erasing certain age-associated features, and illustrating the reversibility potential of aging. Here, we focus on recent advances in the generation of human induced pluripotent stem cells from progeroid syndromes and late-onset diseases such as Alzheimer's or Parkinson's. These cellular models have contributed to a better understanding of such pathologies, as well as to the development of novel therapeutic approaches. We also discuss different strategies to identify and target age-associated reprogramming barriers to facilitate the treatment of age-related disorders.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Soria-Valles C,López-Otín Cdoi
10.1016/j.molmed.2016.05.010subject
Has Abstractpub_date
2016-08-01 00:00:00pages
713-724issue
8eissn
1471-4914issn
1471-499Xpii
S1471-4914(16)30045-4journal_volume
22pub_type
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pub_type： 评论,杂志文章
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2008-07-01 00:00:00
