Abstract：
:Alterations in histone lysine methylation and other epigenetic regulators of gene expression contribute to changes in brain transcriptomes in mood and psychosis spectrum disorders, including depression and schizophrenia. Genetic association studies and animal models implicate multiple lysine methyltransferases and demethylases in the neurobiology of emotion and cognition. Here, we review the role of histone lysine methylation and transcriptional regulation in normal and diseased neurodevelopment and discuss various methyltransferases and demethylases as potential therapeutic targets in the treatment of neuropsychiatric disease.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Peter CJ,Akbarian Sdoi
10.1016/j.molmed.2011.02.003subject
Has Abstractpub_date
2011-07-01 00:00:00pages
372-9issue
7eissn
1471-4914issn
1471-499Xpii
S1471-4914(11)00030-Xjournal_volume
17pub_type
杂志文章,评审abstract：:Adult skeletal muscle has remarkable regenerative potential, which is mainly attributable to a small population of undifferentiated skeletal muscle precursors called satellite cells. These cells reside underneath the basal lamina of skeletal myofibers and can be activated to proliferate, differentiate and fuse to form...
journal_title：Trends in molecular medicine
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abstract：:Children suffering from infectious diseases, both bacterial and viral, are often treated with empirical antibiotics. Keeping in mind both the menace of microorganisms and antibiotic toxicity, it is imperative to develop point-of-care testing (POCT) to discriminate bacterial from viral infections, and to define indicat...
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abstract：:The social amoeba Dictyostelium discoideum is increasingly being used as a simple model for the investigation of problems that are relevant to human health. This article focuses on several recent examples of Dictyostelium-based biomedical research, including the analysis of immune-cell disease and chemotaxis, centroso...
journal_title：Trends in molecular medicine
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abstract：:The surfaces of all vertebrate cells are decorated with a dense and complex array of sugar chains, which are mostly attached to proteins and lipids. Most soluble secreted proteins are also similarly decorated with such glycans. Sialic acids are a diverse family of sugar units with a nine-carbon backbone that are typic...
journal_title：Trends in molecular medicine
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abstract：:Rearrangements of the MLL gene, which is located at chromosome 11q23, are associated with aggressive acute leukemias in both children and adults. MLL regulates Hox gene expression through direct promoter binding and histone modification. MLL rearrangements occurring in leukemia include MLL fusion genes, partial tandem...
journal_title：Trends in molecular medicine
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abstract：:Our understanding and utilization of fecal microbiota transplantation (FMT) has jump-started over the past two decades. Recent technological advancements in sequencing and metabolomics have allowed for better characterization of our intestinal microbial counterparts, triggering a surge of excitement in the fields of m...
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2008-10-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2011.12.002
更新日期：2012-03-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2015.08.001
更新日期：2015-10-01 00:00:00
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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doi：10.1016/j.molmed.2006.08.004
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/s1471-4914(02)02395-x
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abstract：:Innovative sequencing techniques now allow the routine access of whole genomes of pathogens, generating vast amounts of data. Phylogenetic trees are a common method for synthesizing this information. Unfortunately, these trees are often seen only as a visual support to guide researchers, thus neglecting the value of e...
journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 评论,杂志文章
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abstract：:Serotonin is an important neurohormonal factor that has been implicated in cardiovascular function. It can regulate vascular tone, act directly on cardiomyocytes and stimulate chemosensitive nerves in the heart. Cardiovascular dysfunction is observed when serotonin signaling is altered or when variation in serotonin c...
journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
abstract：:Defects in the regulation of apoptosis (programmed cell death) contribute to many diseases, including pathologies associated with cell loss (e.g. stroke, heart failure, neurodegeneration and AIDS), and disorders characterized by a failure to eliminate harmful cells (e.g. cancer, autoimmunity). Apoptosis is caused by a...
journal_title：Trends in molecular medicine
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abstract：:Cardiovascular diseases predominantly result from atherosclerosis, a natural biological phenomenon reflecting food intake and energy production in humans. Lipolysis of plasma triglyceride-rich lipoproteins (TGRLs) by lipoprotein lipase (LPL) is an essential element of energy production that delivers free fatty acids t...
journal_title：Trends in molecular medicine
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doi：10.1016/j.molmed.2020.07.005
更新日期：2020-12-01 00:00:00
