Abstract：
:Cardiovascular diseases predominantly result from atherosclerosis, a natural biological phenomenon reflecting food intake and energy production in humans. Lipolysis of plasma triglyceride-rich lipoproteins (TGRLs) by lipoprotein lipase (LPL) is an essential element of energy production that delivers free fatty acids to peripheral cells. High-density lipoprotein (HDL) plays a key role in this process by acquiring surface lipids, including free cholesterol, that are released upon TGRL lipolysis. According to the reverse remnant-cholesterol transport (RRT) hypothesis, such removal of cholesterol from remnant lipoproteins followed by transport to the liver and excretion into the bile represents a major biological function of HDL that is essential for energy production, and which can reduce cholesterol influx into the arterial wall by accelerating the removal of atherogenic TGRL remnants from the circulation.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Kontush Adoi
10.1016/j.molmed.2020.07.005subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1086-1100issue
12eissn
1471-4914issn
1471-499Xpii
S1471-4914(20)30184-2journal_volume
26pub_type
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
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