Abstract:
:While the hippocampus has long been recognized as a brain structure specialized in mapping 'space' in rodents, human studies and now recent data from rodents have shown that its function extends well beyond spatial coding. Recently, an overlooked area of the hippocampus, CA2, has emerged as a critical region for social memory. This area is also uniquely altered during several pathologies such as schizophrenia and age-related dementia. Because of its singular connectivity, we propose that area CA2 resides at the interface between emotional brain activity and higher cognitive function. Furthermore, because of the unique expression of multiple neuromodulator receptors in area CA2, we posit that this region may represent a fruitful therapeutic target for diseases where social dysfunction occurs.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Chevaleyre V,Piskorowski RAdoi
10.1016/j.molmed.2016.06.007subject
Has Abstractpub_date
2016-08-01 00:00:00pages
645-655issue
8eissn
1471-4914issn
1471-499Xpii
S1471-4914(16)30055-7journal_volume
22pub_type
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