Abstract:
:Non-viral DNA vectors have several advantages over viral vectors. For example, virus production is expensive and there are safety concerns regarding viral manipulations. In addition, the size of the delivered plasmid is limited by the size of the viral capsid, whereas this is not a problem with non-viral vectors. The major disadvantage of using non-viral DNA delivery vectors, compared with their viral counterparts, is the low transfection efficiency. This has resulted in low levels of usage in clinical trials. Consequently, the majority of research into non-viral gene therapy has been focused on developing more efficient vectors.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Schmidt-Wolf GD,Schmidt-Wolf IGdoi
10.1016/s1471-4914(03)00005-4keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
67-72issue
2eissn
1471-4914issn
1471-499Xpii
S1471491403000054journal_volume
9pub_type
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