Abstract：
:Anxiety-related and metabolic disorders are under intense research focus. Anxiety-induced microRNAs (miRNAs) are emerging as regulators that are not only capable of suppressing inflammation but can also induce metabolic syndrome-related processes. We summarize here evidence linking miRNA pathways which share regulatory networks in metabolic and anxiety-related conditions. In particular, miRNAs involved in these disorders include regulators of acetylcholine signaling in the nervous system and their accompanying molecular machinery. These have been associated with anxiety-prone states in individuals, while also acting as inflammatory suppressors. In peripheral tissues, altered miRNA pathways can lead to dysregulated metabolism. Common pathways in metabolic and anxiety-related phenomena might offer an opportunity to reclassify 'healthy' and 'unhealthy', as well as metabolic and anxiety-prone biological states, and inform putative strategies to treat these disorders.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Meydan C,Shenhar-Tsarfaty S,Soreq Hdoi
10.1016/j.molmed.2016.07.001subject
Has Abstractpub_date
2016-09-01 00:00:00pages
798-812issue
9eissn
1471-4914issn
1471-499Xpii
S1471-4914(16)30076-4journal_volume
22pub_type
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