Abstract：
:Arthritis represents a family of complex joint pathologies responsible for the majority of musculoskeletal conditions. Nearly all diseases within this family, including osteoarthritis, rheumatoid arthritis, and juvenile idiopathic arthritis, are chronic conditions with few or no disease-modifying therapeutics available. Advances in genome engineering technology, most recently with CRISPR-Cas9, have revolutionized our ability to interrogate and validate genetic and epigenetic elements associated with chronic diseases such as arthritis. These technologies, together with cell reprogramming methods, including the use of induced pluripotent stem cells, provide a platform for human disease modeling. We summarize new evidence from genome-wide association studies and genomics that substantiates a genetic basis for arthritis pathogenesis. We also review the potential contributions of genome engineering in the development of new arthritis therapeutics.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Adkar SS,Brunger JM,Willard VP,Wu CL,Gersbach CA,Guilak Fdoi
10.1016/j.molmed.2017.08.002subject
Has Abstractpub_date
2017-10-01 00:00:00pages
917-931issue
10eissn
1471-4914issn
1471-499Xpii
S1471-4914(17)30142-9journal_volume
23pub_type
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pub_type： 临床试验,杂志文章
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更新日期：2002-05-01 00:00:00
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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更新日期：2016-11-01 00:00:00
