An Intestinal Inflammasome - The ILC3-Cytokine Tango.

Abstract:

:The inflammasome is a key regulator of immune responses in the gut. Two recent studies in the journal Cell demonstrate that epithelial inflammasome activation and IL-18 secretion can control intestinal homeostasis or induce autoinflammation. ILC3 cells are triggered to secrete IL-22, regulating IL-18 expression in epithelial cells, in turn modulating homeostasis and inflammation.

journal_name

Trends Mol Med

authors

Gonçalves P,Di Santo JP

doi

10.1016/j.molmed.2016.02.008

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

269-271

issue

4

eissn

1471-4914

issn

1471-499X

pii

S1471-4914(16)00038-1

journal_volume

22

pub_type

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