Abstract:
:The inflammasome is a key regulator of immune responses in the gut. Two recent studies in the journal Cell demonstrate that epithelial inflammasome activation and IL-18 secretion can control intestinal homeostasis or induce autoinflammation. ILC3 cells are triggered to secrete IL-22, regulating IL-18 expression in epithelial cells, in turn modulating homeostasis and inflammation.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Gonçalves P,Di Santo JPdoi
10.1016/j.molmed.2016.02.008subject
Has Abstractpub_date
2016-04-01 00:00:00pages
269-271issue
4eissn
1471-4914issn
1471-499Xpii
S1471-4914(16)00038-1journal_volume
22pub_type
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