Abstract：
:H(2)O(2) is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H(2)O(2) generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel peroxidase family that catalyze the H(2)O(2) reduction reaction in the presence of thioredoxin, thioredoxin reductase and NADPH. Several lines of evidence suggest that 2-Cys peroxiredoxins have dual roles as regulators of the H(2)O(2) signal and as defenders of oxidative stress. In particular, 2-Cys peroxiredoxin appears to provide selective, specific and localized control of receptor-mediated signal transduction. Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Kang SW,Rhee SG,Chang TS,Jeong W,Choi MHdoi
10.1016/j.molmed.2005.10.006keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
571-8issue
12eissn
1471-4914issn
1471-499Xpii
S1471-4914(05)00240-6journal_volume
11pub_type
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