Abstract：
:The social amoeba Dictyostelium discoideum is increasingly being used as a simple model for the investigation of problems that are relevant to human health. This article focuses on several recent examples of Dictyostelium-based biomedical research, including the analysis of immune-cell disease and chemotaxis, centrosomal abnormalities and lissencephaly, bacterial intracellular pathogenesis, and mechanisms of neuroprotective and anti-cancer drug action. The combination of cellular, genetic and molecular biology techniques that are available in Dictyostelium often makes the analysis of these problems more amenable to study in this system than in mammalian cell culture. Findings that have been made in these areas using Dictyostelium have driven research in mammalian systems and have established Dictyostelium as a powerful model for human-disease analysis.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Williams RS,Boeckeler K,Gräf R,Müller-Taubenberger A,Li Z,Isberg RR,Wessels D,Soll DR,Alexander H,Alexander Sdoi
10.1016/j.molmed.2006.07.003subject
Has Abstractpub_date
2006-09-01 00:00:00pages
415-24issue
9eissn
1471-4914issn
1471-499Xpii
S1471-4914(06)00144-4journal_volume
12pub_type
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