Abstract：
:Wound repair is a highly regulated process that requires the interaction of various cell types. It has been shown that cancers use the mechanisms of wound healing to promote their own growth. Therefore, it is of importance to identify common regulators of wound repair and tumor formation and to unravel their functions and mechanisms of action. An exciting example is activin, which acts on multiple cell types in wounds and tumors, thereby promoting healing, but also scar formation and tumorigenesis. Here, we summarize current knowledge on the role of activin in these processes and highlight the therapeutic potential of activin or activin antagonists for the treatment of impaired healing or excessive scarring and cancer, respectively.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Cangkrama M,Wietecha M,Werner Sdoi
10.1016/j.molmed.2020.07.009subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1107-1117issue
12eissn
1471-4914issn
1471-499Xpii
S1471-4914(20)30188-Xjournal_volume
26pub_type
杂志文章,评审abstract：:In his article, Szyf [1] has addressed the key challenges in and the controversies surrounding nongenetic inheritance. However, crucial findings that are important to counter two major criticisms held against transgenerational inheritance, especially in mammals--namely epigenetic memory survival across generations, an...
journal_title：Trends in molecular medicine
pub_type： 评论,信件
doi：10.1016/j.molmed.2015.02.010
更新日期：2015-05-01 00:00:00
abstract：:The identification of functionally relevant polymorphisms of peptidylarginine deiminase 4, an enzyme that catalyzes the post-translational citrullination of proteins, as a rheumatoid arthritis gene is one of the most convincing success stories of complex disease gene mapping to date. In addition to an extensive single...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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abstract：:Tumour classification has traditionally focused on differentiation and cellular morphology, and latterly on the application of genomic approaches. By combining chromatin immunoprecipitation with expression array, it has been possible to identify direct gene targets for transcription factors for nuclear hormone recepto...
journal_title：Trends in molecular medicine
pub_type： 临床试验,杂志文章
doi：10.1016/j.molmed.2008.09.002
更新日期：2008-11-01 00:00:00
abstract：:Aging is characterized by irreversible loss of physiological integrity, often accompanied by an organism's loss of function and increased vulnerability to death. Defects in the mechanisms preserving cellular homeostasis over time may give rise to accelerated aging. Somatic cell reprogramming of aged cells can be assoc...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2016.05.010
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
abstract：:Therapy for hepatitis C virus (HCV) infection is on the cusp of a new era. Until now, standard-of-care therapy has involved interferon (IFN) and ribavirin. With the first successful Phase III trials of specific targeted antiviral therapy for HCV (STAT-C) compounds, as well as three trials in progress giving the first ...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 杂志文章
doi：10.1016/j.molmed.2006.03.002
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pub_type： 杂志文章
doi：10.1016/j.molmed.2003.12.001
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journal_title：Trends in molecular medicine
pub_type： 杂志文章
doi：10.1016/j.molmed.2014.05.004
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journal_title：Trends in molecular medicine
pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
abstract：:Defects in the regulation of apoptosis (programmed cell death) contribute to many diseases, including pathologies associated with cell loss (e.g. stroke, heart failure, neurodegeneration and AIDS), and disorders characterized by a failure to eliminate harmful cells (e.g. cancer, autoimmunity). Apoptosis is caused by a...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2006-09-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章
doi：10.1016/j.molmed.2014.08.003
更新日期：2014-10-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2011-10-01 00:00:00
abstract：:Long-standing difficulties in the in vitro transformation of human cells have been overcome. Using telomerase, several successful oncogene-mediated transformations of human cells have been reported and the following cellular requirements for human cell transformation have been proposed: the maintenance of telomere seq...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2004.09.001
更新日期：2004-11-01 00:00:00
abstract：:There is much evidence suggesting that there is a strong relationship between the deterioration of brain lipid homeostasis, vascular changes and the pathogenesis of Alzheimer's disease (AD). These associations include: (1). recognition that a key cholesterol transporter, apolipoprotein E type 4, acts a major genetic r...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/s1471-4914(03)00007-8
更新日期：2003-03-01 00:00:00
abstract：:Microglia are the resident macrophages of the central nervous system (CNS). They have important physiological functions in maintaining tissue homeostasis but also contribute to CNS pathology. Microglia respond to changes in the microenvironment, and the resulting reactive phenotype can be very diverse, with both neuro...
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pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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abstract：:While the hippocampus has long been recognized as a brain structure specialized in mapping 'space' in rodents, human studies and now recent data from rodents have shown that its function extends well beyond spatial coding. Recently, an overlooked area of the hippocampus, CA2, has emerged as a critical region for socia...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2016-08-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2020-04-01 00:00:00
abstract：:While preclinical studies have reported improvement of behavioral deficits in the Ts65Dn mouse model of Down syndrome (DS), translation to human clinical trials to improve cognition in individuals with DS has had a poor success record. Timing of the intervention, choice of animal models, strategy for drug selection, a...
journal_title：Trends in molecular medicine
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
abstract：:CD4(+) T cells occupy a central role in the induction and regulation of adaptive immune responses. Activated CD4(+) T helper (Th) cells exert immediate effector functions by producing cytokines and chemokines, providing help for the induction of CD8(+) cytotoxic T lymphocyte responses and memory, and providing help fo...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2010-10-01 00:00:00
abstract：:The surfaces of all vertebrate cells are decorated with a dense and complex array of sugar chains, which are mostly attached to proteins and lipids. Most soluble secreted proteins are also similarly decorated with such glycans. Sialic acids are a diverse family of sugar units with a nine-carbon backbone that are typic...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2008.06.002
更新日期：2008-08-01 00:00:00
