Abstract:
:Microglia are the resident macrophages of the central nervous system (CNS). They have important physiological functions in maintaining tissue homeostasis but also contribute to CNS pathology. Microglia respond to changes in the microenvironment, and the resulting reactive phenotype can be very diverse, with both neuroinflammatory and neuroprotective properties, illustrating the plasticity of these cells. Recent progress in understanding the autoimmune neuroinflammatory disease multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis suggests major roles for microglia in the disease, which have drastically changed our view on the function of microglia in MS.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Voet S,Prinz M,van Loo Gdoi
10.1016/j.molmed.2018.11.005subject
Has Abstractpub_date
2019-02-01 00:00:00pages
112-123issue
2eissn
1471-4914issn
1471-499Xpii
S1471-4914(18)30223-5journal_volume
25pub_type
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