Abstract：
:Sex differences have been clinically documented in numerous neurodegenerative diseases and yet the reasons for these differences are not well understood. Recent studies have found that microglia, the innate immune cells of the central nervous system, are a key cell type involved in neurodegenerative diseases. This cell type displays sex differences in their expression profiles and function. Could these sex differences in microglia explain the sex differences seen in neurodegenerative diseases? How can we further probe these differences to better understand disease mechanisms? In this Opinion, we highlight the recent evidence that microglia have sex differences, factors that contribute to these differences, and how these differences could shed new light on the pathophysiology of neurological diseases.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Kodama L,Gan Ldoi
10.1016/j.molmed.2019.05.001subject
Has Abstractpub_date
2019-09-01 00:00:00pages
741-749issue
9eissn
1471-4914issn
1471-499Xpii
S1471-4914(19)30103-0journal_volume
25pub_type
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