Abstract:
:The mammalian target of rapamycin (mTOR), the key component of the protein complexes mTORC1 and mTORC2, plays a critical role in cellular development, tissue regeneration, and repair. mTOR signaling can govern not only stem cell development and quiescence but also cell death during apoptosis or autophagy. Recent studies highlight the importance of both traditional and newly recognized interactors of mTOR, such as p70S6K, 4EBP1, GSK-3β, REDD1/RTP801, TSC1/TSC2, growth factors, wingless, and forkhead transcription factors, that influence Alzheimer's disease, Parkinson's disease, Huntington's disease, tuberous sclerosis, and epilepsy. Targeting mTOR in the nervous system can offer exciting new avenues of drug discovery, but crucial to this premise is elucidating the complexity of mTOR signaling for robust and safe clinical outcomes.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Maiese K,Chong ZZ,Shang YC,Wang Sdoi
10.1016/j.molmed.2012.11.001subject
Has Abstractpub_date
2013-01-01 00:00:00pages
51-60issue
1eissn
1471-4914issn
1471-499Xpii
S1471-4914(12)00209-2journal_volume
19pub_type
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