Abstract：
:Serotonin is an important neurohormonal factor that has been implicated in cardiovascular function. It can regulate vascular tone, act directly on cardiomyocytes and stimulate chemosensitive nerves in the heart. Cardiovascular dysfunction is observed when serotonin signaling is altered or when variation in serotonin concentration occurs. Recent studies have provided evidence that, in the absence of peripheral serotonin synthesis, blood serotonin (which is almost exclusively stored in platelets) is markedly reduced, and that this drop leads to heart failure. This implies that the level of circulating serotonin is a key factor in maintaining normal cardiovascular activity. These findings offer new prospects for the use of serotonin in therapies for cardiovascular diseases.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Côté F,Fligny C,Fromes Y,Mallet J,Vodjdani Gdoi
10.1016/j.molmed.2004.03.007keywords:
subject
Has Abstractpub_date
2004-05-01 00:00:00pages
232-8issue
5eissn
1471-4914issn
1471-499Xpii
S1471491404000802journal_volume
10pub_type
杂志文章,评审abstract：:Ten percent of inherited diseases are caused by premature termination codon (PTC) mutations that lead to degradation of the mRNA template and to the production of a non-functional, truncated polypeptide. In addition, many acquired mutations in cancer introduce similar PTCs. In 1999, proof-of-concept for treating these...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2012.09.008
更新日期：2012-11-01 00:00:00
abstract：:Immune checkpoint inhibitors (ICIs) have revolutionised cancer immunotherapy but their success is wholly dependent on amplifying an existing immune response directed against the tumour. A recent study by Tsuchiya et al. suggests how the properties of induced pluripotent stem cells (iPSCs) may be exploited for the targ...
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abstract：:Targeting pathological tau protein in Alzheimer's disease (AD) and related tauopathies has shown great potential in animal models. Given that tau lesions correlate better with the degree of dementia than do amyloid-β (Aβ) plaques, their clearance may be clinically more efficacious than removing Aβ when cognitive defic...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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abstract：:After years of continuous exposure to HIV envelope antigens, a minority of HIV-infected individuals develop a cognate polyclonal humoral response comprising very potent and extremely cross-reactive neutralizing antibodies [broadly neutralizing antibodies (bNAbs)]. Isolated bNAbs derived from memory B cell pools have b...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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abstract：:The social amoeba Dictyostelium discoideum is increasingly being used as a simple model for the investigation of problems that are relevant to human health. This article focuses on several recent examples of Dictyostelium-based biomedical research, including the analysis of immune-cell disease and chemotaxis, centroso...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2006-09-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 杂志文章
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2017-07-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2015-09-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2016-09-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2019-08-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章
doi：10.1016/s1471-4914(02)02276-1
更新日期：2002-02-01 00:00:00
abstract：:Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imagin...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
abstract：:Clustered regularly interspaced short palindromic repeats, or CRISPR, has been widely accepted as a versatile genome editing tool with significant potential for medical application. Reliable allele specificity is one of the most critical elements for successful application of this technology to develop high-precision ...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2020-03-01 00:00:00
abstract：:B lymphocytes are essential for an efficient immune response against a variety of pathogens. A large fraction of hematologic malignancies is of B cell origin, suggesting that the development and activation of B cells need to be tightly regulated. In recent years, increasing evidence has emerged demonstrating that micr...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2017.06.001
更新日期：2017-08-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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abstract：:For decades it has been assumed that T cells reject tumors essentially by direct killing. However, solid tumors are composed of malignant cells and a variety of different nonmalignant cells, referred to as tumor stroma. Stromal cells, such as endothelial cells, fibroblasts and inflammatory cells, often support tumor g...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2005.03.002
更新日期：2005-05-01 00:00:00
abstract：:As gene therapy begins to produce its first clinical successes, interest in ocular gene transfer has grown owing to the favorable safety and efficacy characteristics of the eye as a target organ for drug delivery. Important advances also include the availability of viral and non-viral vectors that are able to efficien...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2008.11.003
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abstract：:Patients who survive a stroke have an increased risk for recurrent vascular events. The mechanisms underlying the events are barely understood. A recent study suggests that stroke-enhanced atherosclerosis is induced through brain-released alarmins, which lead to systemic vascular inflammation and plaque formation. Int...
journal_title：Trends in molecular medicine
pub_type： 评论,杂志文章
doi：10.1016/j.molmed.2018.04.008
更新日期：2018-07-01 00:00:00
abstract：:Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on cellular signal transduction and accumulating evidence indicates important roles for S-nitrosylation both in normal physiology and in a broad spectrum of human diseases. Here we review recent findings that implicate S-nitro...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
doi：10.1016/j.molmed.2009.06.007
更新日期：2009-09-01 00:00:00
abstract：:Inflammatory signaling underlies many diseases, from arthritis to cancer. Our understanding of inflammation has thus far been limited to the world of proteins, because we are only just beginning to understand the role that noncoding RNAs (ncRNA) might play. It is now clear that ncRNA do not constitute transcriptional ...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2001-04-01 00:00:00
abstract：:The B cell arm of the immune response becomes activated soon after HIV-1 transmission, yet the initial antibody response does not control HIV-1 replication, and it takes months for neutralizing antibodies to develop against the autologous virus. Antibodies that can be broadly protective are made only in a minority of ...
journal_title：Trends in molecular medicine
pub_type： 杂志文章
doi：10.1016/j.molmed.2010.10.008
更新日期：2011-02-01 00:00:00
abstract：:The inflammasome is a key regulator of immune responses in the gut. Two recent studies in the journal Cell demonstrate that epithelial inflammasome activation and IL-18 secretion can control intestinal homeostasis or induce autoinflammation. ILC3 cells are triggered to secrete IL-22, regulating IL-18 expression in epi...
journal_title：Trends in molecular medicine
pub_type： 评论,杂志文章
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abstract：:Medulloblastomas often activate Hedgehog signaling inappropriately. The finding that mutations in components of this pathway are present only in few tumors suggests that additional genetic or epigenetic lesions can also lead to Hedgehog dysregulation. Chromosome 17p deletion, the most frequently detected genetic lesio...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2005-12-01 00:00:00
abstract：:Recent reports on the impressive efficacy of adoptively transferred T cells to challenge cancer in early phase clinical trials have significantly raised the profile of T cell therapy. Concomitantly, general expectations are also raised by these reports, with the natural aspiration to deliver this therapy over a wide r...
journal_title：Trends in molecular medicine
pub_type： 杂志文章,评审
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更新日期：2012-07-01 00:00:00
abstract：:In STEM, and particularly in science, many early career researchers find themselves isolated and lacking guidance. There is an enormous need to connect early career scientists with experienced professionals outside their immediate work environment. A new initiative aims to create a supportive community to foster commu...
journal_title：Trends in molecular medicine
pub_type： 社论
doi：10.1016/j.molmed.2019.08.007
更新日期：2019-11-01 00:00:00
