Inflammation meets oxidation: NF-kappaB as a mediator of initial lesion development in atherosclerosis.

Abstract:

:Transcription factor nuclear factor-kappaB (NF-kappaB) and its target genes are involved in the pathogenesis of atherosclerosis, in addition to many other diseases. Monocyte recruitment into subendothelial space is primarily mediated by NF-kappaB-dependent gene expression, and this event is a crucial milestone, because it is nearly impossible to reverse the progression of the lesion after this point. Recent advances in our understanding of atherosclerosis as a disease of childhood enforces the necessity of developing novel approaches for prevention and treatment. Here, the authors address NF-kappaB as a major therapeutic target, especially for preventive measures, in the light of two main hypotheses of atherosclerosis: oxidation and inflammation.

journal_name

Trends Mol Med

authors

Kutuk O,Basaga H

doi

10.1016/j.molmed.2003.10.007

keywords:

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

549-57

issue

12

eissn

1471-4914

issn

1471-499X

pii

S1471491403002429

journal_volume

9

pub_type

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