Abstract:
:Transcription factor nuclear factor-kappaB (NF-kappaB) and its target genes are involved in the pathogenesis of atherosclerosis, in addition to many other diseases. Monocyte recruitment into subendothelial space is primarily mediated by NF-kappaB-dependent gene expression, and this event is a crucial milestone, because it is nearly impossible to reverse the progression of the lesion after this point. Recent advances in our understanding of atherosclerosis as a disease of childhood enforces the necessity of developing novel approaches for prevention and treatment. Here, the authors address NF-kappaB as a major therapeutic target, especially for preventive measures, in the light of two main hypotheses of atherosclerosis: oxidation and inflammation.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Kutuk O,Basaga Hdoi
10.1016/j.molmed.2003.10.007keywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
549-57issue
12eissn
1471-4914issn
1471-499Xpii
S1471491403002429journal_volume
9pub_type
杂志文章,评审abstract::Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease. It leads to irreversible joint damage, physical handicap, and reduced life expectancy. The past two decades have seen considerable therapeutic advances with the development of biologic treatments to block proinflammatory cytokines or modulate...
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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doi:10.1016/j.molmed.2004.05.004
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pub_type: 临床试验,杂志文章
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journal_title:Trends in molecular medicine
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pub_type: 评论,杂志文章
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pub_type: 杂志文章
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pub_type: 评论,杂志文章
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