Sialic acids in human health and disease.

Abstract:

:The surfaces of all vertebrate cells are decorated with a dense and complex array of sugar chains, which are mostly attached to proteins and lipids. Most soluble secreted proteins are also similarly decorated with such glycans. Sialic acids are a diverse family of sugar units with a nine-carbon backbone that are typically found attached to the outermost ends of these chains. Given their location and ubiquitous distribution, sialic acids can mediate or modulate a wide variety of physiological and pathological processes. This review considers some examples of their established and newly emerging roles in aspects of human physiology and disease.

journal_name

Trends Mol Med

authors

Varki A

doi

10.1016/j.molmed.2008.06.002

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

351-60

issue

8

eissn

1471-4914

issn

1471-499X

pii

S1471-4914(08)00133-0

journal_volume

14

pub_type

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