Meet Your Stress Management Professionals: The Endocannabinoids.

Abstract:

:The endocannabinoid signaling system (ECSS) is altered by exposure to stress and mediates and modulates the effects of stress on the brain. Considerable preclinical data support critical roles for the endocannabinoids and their target, the CB1 cannabinoid receptor, in the adaptation of the brain to repeated stress exposure. Chronic stress exposure increases vulnerability to mental illness, so the ECSS has attracted attention as a potential therapeutic target for the prevention and treatment of stress-related psychopathology. We discuss human genetic studies indicating that the ECSS contributes to risk for mental illness in those exposed to severe stress and trauma early in life, and we explore the potential difficulties in pharmacological manipulation of the ECSS.

journal_name

Trends Mol Med

authors

deRoon-Cassini TA,Stollenwerk TM,Beatka M,Hillard CJ

doi

10.1016/j.molmed.2020.07.002

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

953-968

issue

10

eissn

1471-4914

issn

1471-499X

pii

S1471-4914(20)30177-5

journal_volume

26

pub_type

杂志文章,评审
  • Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery.

    abstract::The efficacy of drugs administered by traditional routes is limited by numerous biological barriers that preclude reaching the intended site of action. Further, full body systemic exposure leads to dose-limiting, off-target side effects. Topical formulations may provide more efficacious drug and nucleic acid delivery ...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2020.12.001

    authors: Zierden HC,Josyula A,Shapiro RL,Hsueh HT,Hanes J,Ensign LM

    更新日期:2021-01-04 00:00:00

  • Clinical applications of pathogen phylogenies.

    abstract::Innovative sequencing techniques now allow the routine access of whole genomes of pathogens, generating vast amounts of data. Phylogenetic trees are a common method for synthesizing this information. Unfortunately, these trees are often seen only as a visual support to guide researchers, thus neglecting the value of e...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2014.04.002

    authors: Hartfield M,Murall CL,Alizon S

    更新日期:2014-07-01 00:00:00

  • Genome Engineering for Personalized Arthritis Therapeutics.

    abstract::Arthritis represents a family of complex joint pathologies responsible for the majority of musculoskeletal conditions. Nearly all diseases within this family, including osteoarthritis, rheumatoid arthritis, and juvenile idiopathic arthritis, are chronic conditions with few or no disease-modifying therapeutics availabl...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2017.08.002

    authors: Adkar SS,Brunger JM,Willard VP,Wu CL,Gersbach CA,Guilak F

    更新日期:2017-10-01 00:00:00

  • Towards a molecular understanding of human diseases using Dictyostelium discoideum.

    abstract::The social amoeba Dictyostelium discoideum is increasingly being used as a simple model for the investigation of problems that are relevant to human health. This article focuses on several recent examples of Dictyostelium-based biomedical research, including the analysis of immune-cell disease and chemotaxis, centroso...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2006.07.003

    authors: Williams RS,Boeckeler K,Gräf R,Müller-Taubenberger A,Li Z,Isberg RR,Wessels D,Soll DR,Alexander H,Alexander S

    更新日期:2006-09-01 00:00:00

  • Senescent Cells Drive Frailty through Systemic Signals.

    abstract::Senescent cells drive ageing and the associated loss in health and lifespan. Whether this is mediated by systemic signalling remained unclear. Recently, Xu et al. [1] (Nat. Med. 2018;24:1246-1256) answered this question by injecting senescent cells into young mice and observing a long-lasting increase in frailty and m...

    journal_title:Trends in molecular medicine

    pub_type: 评论,杂志文章

    doi:10.1016/j.molmed.2018.09.003

    authors: Lehmann J,Baar MP,de Keizer PLJ

    更新日期:2018-11-01 00:00:00

  • Polycystin-1: a master regulator of intersecting cystic pathways.

    abstract::Autosomal dominant polycystic kidney disease (ADPKD) is the most common potentially lethal monogenic disorder, with more than 12 million cases worldwide. The two causative genes for ADPKD, PKD1 and PKD2, encode protein products polycystin-1 (PC1) and polycystin-2 (PC2 or TRPP2), respectively. Recent data have shed lig...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2014.01.004

    authors: Fedeles SV,Gallagher AR,Somlo S

    更新日期:2014-05-01 00:00:00

  • Early Detection of Cancer in Blood Using Single-Cell Analysis: A Proposal.

    abstract::Here, we explore the potential of single-cell genomic analysis in blood for early detection of cancer; we consider a method that screens the presence of recurrent patterns of copy number (CN) alterations using sparse single-cell sequencing. We argue for feasibility, based on in silico analysis of existing single-cell ...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2017.05.005

    authors: Krasnitz A,Kendall J,Alexander J,Levy D,Wigler M

    更新日期:2017-07-01 00:00:00

  • Foci on fanconi.

    abstract::The protein network protecting the stability of the genome is defective in Fanconi anemia (FA). The newest in a series of FA proteins is involved in DNA damage response, but the mechanism is still unclear. Clues may come from yeast two-hybrid experiments, an extraordinarily successful tool for determining molecular fu...

    journal_title:Trends in molecular medicine

    pub_type: 新闻

    doi:10.1016/s1471-4914(01)02042-1

    authors: Hoatlin M,Reuter T

    更新日期:2001-06-01 00:00:00

  • Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia.

    abstract::The placenta is central to foetal growth and development in mammalian pregnancy. Compromised placental function (as found in pre-eclampsia) often results in life-threatening situations for both mother and foetus. The nitric-oxide (NO) signalling cascade is important for placental function, in particular for the develo...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2006.03.003

    authors: Vatish M,Randeva HS,Grammatopoulos DK

    更新日期:2006-05-01 00:00:00

  • Wound Repair, Scar Formation, and Cancer: Converging on Activin.

    abstract::Wound repair is a highly regulated process that requires the interaction of various cell types. It has been shown that cancers use the mechanisms of wound healing to promote their own growth. Therefore, it is of importance to identify common regulators of wound repair and tumor formation and to unravel their functions...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2020.07.009

    authors: Cangkrama M,Wietecha M,Werner S

    更新日期:2020-12-01 00:00:00

  • Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology.

    abstract::Microglia are the resident macrophages of the central nervous system (CNS). They have important physiological functions in maintaining tissue homeostasis but also contribute to CNS pathology. Microglia respond to changes in the microenvironment, and the resulting reactive phenotype can be very diverse, with both neuro...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2018.11.005

    authors: Voet S,Prinz M,van Loo G

    更新日期:2019-02-01 00:00:00

  • iPSCs for personalized medicine: what will it take for Africa?

    abstract::Induced pluripotent stem cells (iPSCs) are cutting edge biotechnology that may revolutionize medicine, and creating iPSCs from ethnically diverse individuals would generate valuable therapeutic and drug development tools. However, challenges must be overcome in creating the infrastructure and scientific capacity neede...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章

    doi:10.1016/j.molmed.2012.10.005

    authors: Fakunle ES

    更新日期:2012-12-01 00:00:00

  • Epigenetic modifications in trinucleotide repeat diseases.

    abstract::Accumulating evidence supports the important role for epigenetic changes in modulating clinical parameters of complex disorders, including neurodegenerative disease. Several conditions, including fragile X syndrome and Huntington's disease are caused by trinucleotide repeat (TNR) expansions in or near specific genes. ...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2013.07.007

    authors: Evans-Galea MV,Hannan AJ,Carrodus N,Delatycki MB,Saffery R

    更新日期:2013-11-01 00:00:00

  • Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing.

    abstract::Children suffering from infectious diseases, both bacterial and viral, are often treated with empirical antibiotics. Keeping in mind both the menace of microorganisms and antibiotic toxicity, it is imperative to develop point-of-care testing (POCT) to discriminate bacterial from viral infections, and to define indicat...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2020.09.004

    authors: Tsao YT,Tsai YH,Liao WT,Shen CJ,Shen CF,Cheng CM

    更新日期:2020-12-01 00:00:00

  • RBC NOS: regulatory mechanisms and therapeutic aspects.

    abstract::Nitric oxide (NO), one of the most important vascular signaling molecules, is primarily produced by endothelial NO synthase (eNOS). eNOS is tightly regulated by its substrate l-arginine, cofactors and diverse interacting proteins. Interestingly, an NO synthase (NOS) was described within red blood cells (RBC NOS), and ...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2008.05.002

    authors: Ozüyaman B,Grau M,Kelm M,Merx MW,Kleinbongard P

    更新日期:2008-07-01 00:00:00

  • Signaling to NF-kappaB by Toll-like receptors.

    abstract::Innate immunity is the first line of defense against invading pathogens. A family of Toll-like receptors (TLRs) acts as primary sensors that detect a wide variety of microbial components and elicit innate immune responses. All TLR signaling pathways culminate in activation of the transcription factor nuclear factor-ka...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2007.09.002

    authors: Kawai T,Akira S

    更新日期:2007-11-01 00:00:00

  • Pregnancy Around the Clock.

    abstract::A recent study introduced the existence of an 'immune clock' in pregnancy; during the course of gestation, peripheral blood cells from pregnant women were analyzed by mass cytometry using a single-cell signaling-based elastic net algorithm. The insights will undoubtedly promote the testing of such a clock - possibly i...

    journal_title:Trends in molecular medicine

    pub_type: 评论,杂志文章

    doi:10.1016/j.molmed.2017.11.007

    authors: Diemert A,Arck PC

    更新日期:2018-01-01 00:00:00

  • Strengthening Causal Inference for Complex Disease Using Molecular Quantitative Trait Loci.

    abstract::Large genome-wide association studies (GWAS) have identified loci that are associated with complex traits and diseases, but index variants are often not causal and reside in non-coding regions of the genome. To gain a better understanding of the relevant biological mechanisms, intermediate traits such as gene expressi...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2019.10.004

    authors: Neumeyer S,Hemani G,Zeggini E

    更新日期:2020-02-01 00:00:00

  • Autophagy as a basis for the health-promoting effects of vitamin D.

    abstract::Autophagy is an evolutionarily conserved lysosomal self-digestion process essential for cellular homeostasis, differentiation and survival. As an adaptive response, it protects organisms against a wide range of pathologies, including cancer, infection, neurodegeneration, heart disease and ageing. Thus, compounds activ...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章

    doi:10.1016/j.molmed.2010.04.005

    authors: Høyer-Hansen M,Nordbrandt SP,Jäättelä M

    更新日期:2010-07-01 00:00:00

  • Dispelling myths and focusing on notable concepts in HIV pathogenesis.

    abstract::Since the discovery of HIV over three decades ago, major efforts have been made to control and perhaps eliminate HIV infection worldwide. During these studies, certain myths or misconceptions about this infectious disease have been emphasized and other potentially beneficial concepts have received less attention. A tr...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2015.03.004

    authors: Levy JA

    更新日期:2015-06-01 00:00:00

  • Translational Neuroendocrinology of Human Skin: Concepts and Perspectives.

    abstract::Human skin responds to numerous neurohormones, neuropeptides, and neurotransmitters that reach it via the vasculature or skin nerves, and/or are generated intracutaneously, thus acting in a para- and autocrine manner. This review focuses on how neurohormones impact on human skin physiology and pathology. We highlight ...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2020.09.002

    authors: Ramot Y,Böhm M,Paus R

    更新日期:2021-01-01 00:00:00

  • MicroRNA Regulators of Anxiety and Metabolic Disorders.

    abstract::Anxiety-related and metabolic disorders are under intense research focus. Anxiety-induced microRNAs (miRNAs) are emerging as regulators that are not only capable of suppressing inflammation but can also induce metabolic syndrome-related processes. We summarize here evidence linking miRNA pathways which share regulator...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2016.07.001

    authors: Meydan C,Shenhar-Tsarfaty S,Soreq H

    更新日期:2016-09-01 00:00:00

  • The role of innate immunity activation in house dust mite allergy.

    abstract::House dust mite (HDM) allergy is a frequent inflammatory disease found worldwide. Although allergen-specific CD4(+) Th2 cells orchestrate the HDM allergic response, notably through induction of IgE directed towards mite allergens, recent studies have demonstrated that innate immunity activation also plays a critical r...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2011.05.014

    authors: Jacquet A

    更新日期:2011-10-01 00:00:00

  • Recent advances in understanding migraine mechanisms, molecules and therapeutics.

    abstract::Migraine is a complex, disabling disorder of the brain that manifests itself as attacks of often severe, throbbing head pain with sensory sensitivity to light, sound and head movement. There is a clear familial tendency to migraine, which has been well defined in a rare autosomal dominant form of familial hemiplegic m...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2006.11.005

    authors: Goadsby PJ

    更新日期:2007-01-01 00:00:00

  • Advances in epigenome-wide association studies for common diseases.

    abstract::Epigenome-wide association studies (EWASs) provide a systematic approach to uncovering epigenetic variants underlying common diseases. Discoveries have shed light on novel molecular mechanisms of disease and enabled the application of epigenetic variants as biomarkers. Here, we highlight the recent advances in this em...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章

    doi:10.1016/j.molmed.2014.07.002

    authors: Paul DS,Beck S

    更新日期:2014-10-01 00:00:00

  • Cyclic dipeptides: from bugs to brain.

    abstract::Cyclic dipeptides (CDPs) are a group of hormone-like molecules that are evolutionarily conserved from bacteria to humans. In bacteria, CDPs are used in quorum sensing (QS) to communicate information about population size and to regulate a behavioural switch from symbiosis with their host to virulence. In mammals, CDPs...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章

    doi:10.1016/j.molmed.2014.08.003

    authors: Bellezza I,Peirce MJ,Minelli A

    更新日期:2014-10-01 00:00:00

  • Promoting brain remodeling to aid in stroke recovery.

    abstract::Endogenous brain repair after stroke involves a set of highly interactive processes, such as angiogenesis, neurogenesis, oligodendrogenesis, synaptogenesis, and axonal outgrowth, which together orchestrate neurological recovery. During the past several years, there have been advances in our understanding of miRNAs and...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2015.07.005

    authors: Zhang ZG,Chopp M

    更新日期:2015-09-01 00:00:00

  • Tools for Bioimaging Pancreatic β Cells in Diabetes.

    abstract::When diabetes is diagnosed, the majority of insulin-secreting pancreatic β cells are already dysfunctional or destroyed. This β cell dysfunction/destruction usually takes place over many years, making timely detection and clinical intervention difficult. For this reason, there is immense interest in developing tools t...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2019.05.004

    authors: Kang NY,Soetedjo AAP,Amirruddin NS,Chang YT,Eriksson O,Teo AKK

    更新日期:2019-08-01 00:00:00

  • Molecular and immune toxicity of CoCr nanoparticles in MoM hip arthroplasty.

    abstract::Theoretical, desirable features of second-generation metal-on-metal (MoM) hip prostheses have led to their widespread use. However, the bearing surfaces, consisting of complex cobalt-chromium alloys, are subject to wear and the release of cobalt and chromium (CoCr) nanoparticles. These nanoparticles can reduce cellula...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2011.12.002

    authors: Gill HS,Grammatopoulos G,Adshead S,Tsialogiannis E,Tsiridis E

    更新日期:2012-03-01 00:00:00

  • Loss of autoimmune T cells correlates with brain diseases: possible implications for schizophrenia?

    abstract::T-cell-mediated autoimmunity participates in physiological defense, maintenance and repair of the adult brain. However, unless such autoimmune responses to insults are rigorously controlled, they might lead to an autoimmune disease or other immune-related defects, where destructive activity outweighs the beneficial ef...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章

    doi:10.1016/j.molmed.2006.01.003

    authors: Kipnis J,Cardon M,Strous RD,Schwartz M

    更新日期:2006-03-01 00:00:00