Abstract:
:B lymphocytes are essential for an efficient immune response against a variety of pathogens. A large fraction of hematologic malignancies is of B cell origin, suggesting that the development and activation of B cells need to be tightly regulated. In recent years, increasing evidence has emerged demonstrating that microRNAs (miRNAs) - a class of non-coding RNAs that control gene expression - are involved in the regulation of B cell development and function. We provide here an overview of the current knowledge on the role of miRNAs and their relevant targets in B cell development, B cell activation, and B cell malignant transformation.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Coffre M,Koralov SBdoi
10.1016/j.molmed.2017.06.001subject
Has Abstractpub_date
2017-08-01 00:00:00pages
721-736issue
8eissn
1471-4914issn
1471-499Xpii
S1471-4914(17)30098-9journal_volume
23pub_type
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