Can Nucleoli Be Markers of Developmental Potential in Human Zygotes?

Abstract:

:In 1999, Tesarik and Greco reported that they could predict the developmental potential of human zygotes from a single static evaluation of their pronuclei. This was based on the distribution and number of specific nuclear organelles - the nucleoli. Recent studies in mice show that nucleoli play a key role in parental genome restructuring after fertilization, and that interfering with this process may lead to developmental failure. These studies thus support the Tesarik-Greco evaluation as a potentially useful method for selecting high-quality embryos in human assisted reproductive technologies. In this opinion article we discuss recent evidence linking nucleoli to parental genome reprogramming, and ask whether nucleoli can mirror or be used as representative markers of embryonic parameters such as chromosome content or DNA fragmentation.

journal_name

Trends Mol Med

authors

Fulka H,Kyogoku H,Zatsepina O,Langerova A,Fulka J Jr

doi

10.1016/j.molmed.2015.09.005

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

663-672

issue

11

eissn

1471-4914

issn

1471-499X

pii

S1471-4914(15)00179-3

journal_volume

21

pub_type

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