Abstract:
:In 1999, Tesarik and Greco reported that they could predict the developmental potential of human zygotes from a single static evaluation of their pronuclei. This was based on the distribution and number of specific nuclear organelles - the nucleoli. Recent studies in mice show that nucleoli play a key role in parental genome restructuring after fertilization, and that interfering with this process may lead to developmental failure. These studies thus support the Tesarik-Greco evaluation as a potentially useful method for selecting high-quality embryos in human assisted reproductive technologies. In this opinion article we discuss recent evidence linking nucleoli to parental genome reprogramming, and ask whether nucleoli can mirror or be used as representative markers of embryonic parameters such as chromosome content or DNA fragmentation.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Fulka H,Kyogoku H,Zatsepina O,Langerova A,Fulka J Jrdoi
10.1016/j.molmed.2015.09.005subject
Has Abstractpub_date
2015-11-01 00:00:00pages
663-672issue
11eissn
1471-4914issn
1471-499Xpii
S1471-4914(15)00179-3journal_volume
21pub_type
杂志文章,评审abstract::There is much evidence suggesting that there is a strong relationship between the deterioration of brain lipid homeostasis, vascular changes and the pathogenesis of Alzheimer's disease (AD). These associations include: (1). recognition that a key cholesterol transporter, apolipoprotein E type 4, acts a major genetic r...
journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
pub_type: 评论,杂志文章
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Trends in molecular medicine
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doi:10.1016/j.molmed.2009.02.002
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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更新日期:2020-10-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2016.05.010
更新日期:2016-08-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2020.12.001
更新日期:2021-01-04 00:00:00
abstract::The surfaces of all vertebrate cells are decorated with a dense and complex array of sugar chains, which are mostly attached to proteins and lipids. Most soluble secreted proteins are also similarly decorated with such glycans. Sialic acids are a diverse family of sugar units with a nine-carbon backbone that are typic...
journal_title:Trends in molecular medicine
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doi:10.1016/j.molmed.2008.06.002
更新日期:2008-08-01 00:00:00
abstract::The proteins encoded by the breast-cancer-susceptibility genes, BRCA1 and BRCA2, have recently been implicated in DNA-repair processes, thereby improving our understanding of how the loss of these genes contributes to cancer initiation and progression. It appears that the role of BRCA1 in DNA repair, which could invol...
journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2004.09.001
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2009.04.005
更新日期:2009-06-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2006.03.002
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abstract::Epigenome-wide association studies (EWASs) provide a systematic approach to uncovering epigenetic variants underlying common diseases. Discoveries have shed light on novel molecular mechanisms of disease and enabled the application of epigenetic variants as biomarkers. Here, we highlight the recent advances in this em...
journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2014.07.002
更新日期:2014-10-01 00:00:00
abstract::Carbon monoxide, long considered only as a toxic gas, has recently been shown to mediate potent anti-inflammatory and other salutary effects in rodents when it is used at low doses. Carbon monoxide is one of the products of the degradation of heme by heme oxygenase 1. Until recently, these beneficial effects of carbon...
journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2006.06.007
更新日期:2006-08-01 00:00:00
abstract::The vanilloid receptor TRPV1 is now recognized as a molecular integrator of painful stimuli ranging from noxious heat to endovanilloids in inflammation. Pharmacological blockade of TRPV1 represents a new strategy in pain relief. TRPV1 antagonists are expected to prevent pain by silencing receptors where pain is genera...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2006.09.001
更新日期:2006-11-01 00:00:00
abstract::It is now widely accepted that the classic environmental risk factors for atherosclerosis only partly explain the incidence of coronary artery disease and the development of acute coronary syndromes. Therefore, genetic factors that vary among human populations seem to be involved in the clinical manifestations of such...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2008.08.004
更新日期:2008-10-01 00:00:00
abstract::Many organs throughout the body maintain epithelial homeostasis by employing a mucosal barrier which acts as a lubricant and helps to preserve a near-sterile epithelium. Goblet cells are largely responsible for secreting components of this mucosal barrier and represent a major cellular component of the innate defense ...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2015.06.003
更新日期:2015-08-01 00:00:00
abstract::Genome sequencing has the potential for stratified cancer treatment and improved diagnostics for rare disorders. However, sequencing needs to be utilised in risk stratification on a population scale to deepen the impact on the health system by addressing common diseases, where individual genomic variants have variable...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2014.04.001
更新日期:2014-09-01 00:00:00