One ring to rule them all? Another cellular responsibility for PCNA.

Abstract:

:To prevent duplication or loss of genomic regions during DNA replication, it is essential that the entire genome is copied precisely once every S phase. Cells achieve this by mutually exclusive regulation of origin firing and licensing. A crucial protein that is involved in origin licensing is chromatin licensing and DNA replication factor 1 (CDT1) and, therefore, activity of this protein must be strictly controlled. Four recent articles have demonstrated that proliferating cell nuclear antigen (PCNA), an essential sliding clamp used in replication and DNA repair, has a crucial role in this process by mediating the proteasomal degradation of CDT1.

journal_name

Trends Mol Med

authors

Green CM

doi

10.1016/j.molmed.2006.08.004

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

455-8

issue

10

eissn

1471-4914

issn

1471-499X

pii

S1471-4914(06)00173-0

journal_volume

12

pub_type

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