Abstract：
:T-cell-mediated autoimmunity participates in physiological defense, maintenance and repair of the adult brain. However, unless such autoimmune responses to insults are rigorously controlled, they might lead to an autoimmune disease or other immune-related defects, where destructive activity outweighs the beneficial effect. Here, we discuss these apparently contradictory effects of autoimmunity in schizophrenic patients, whose typical immune aberrations have prompted recent speculation about an autoimmune-related etiology. We found that, although schizophrenic patients have active immune systems, they often lack autoimmune clones specifically reactive to a major myelin protein, myelin basic protein (MBP). This, in conjunction with our discovery in rodents that T cells that recognize brain-resident proteins are needed for normal cognitive functioning, led us to propose an immune-based neurodevelopmental hypothesis, in which autoimmune-T-cell deficiency is suggested to cause onset or progression of schizophrenia.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Kipnis J,Cardon M,Strous RD,Schwartz Mdoi
10.1016/j.molmed.2006.01.003keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
107-12issue
3eissn
1471-4914issn
1471-499Xpii
S1471-4914(06)00021-9journal_volume
12pub_type
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