Abstract:
:Clinical medicine of the future is poised to use an individual's genomic data to predict disease risk and guide clinical care. The treatment of cigarette smoking and tobacco use disorder represents a prime area for genomics implementation. The genes CHRNA5 and CYP2A6 are strong genomic contributors that alter the risk of heaviness of smoking, tobacco use disorder, and smoking-related diseases in humans. These biomarkers have proven analytical and clinical validity, and evidence for their clinical utility continues to grow. We propose that these biomarkers harbor the potential of enabling the identification of elevated disease risk in smokers, personalizing smoking cessation treatments, and motivating behavioral changes. We must prepare for the integration of genomic applications into clinical care of patients who smoke.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Bierut LJ,Tyndale RFdoi
10.1016/j.molmed.2017.12.001subject
Has Abstractpub_date
2018-02-01 00:00:00pages
187-196issue
2eissn
1471-4914issn
1471-499Xpii
S1471-4914(17)30213-7journal_volume
24pub_type
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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