CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe.

Abstract:

:Recent reports on the impressive efficacy of adoptively transferred T cells to challenge cancer in early phase clinical trials have significantly raised the profile of T cell therapy. Concomitantly, general expectations are also raised by these reports, with the natural aspiration to deliver this therapy over a wide range of tumor indications. Chimeric antigen receptors (CARs) endow T cell populations with defined antigen specificities that function independently of the natural T cell receptor and permit targeting of T cells towards virtually any tumor. Here, we review the current clinical application of CAR-T cells and relate clinical efficacy and safety of CAR-T cell trials to parameters considered critical for CAR engineering, classified as the three T's of CAR-T cell manipulation.

journal_name

Trends Mol Med

authors

Gilham DE,Debets R,Pule M,Hawkins RE,Abken H

doi

10.1016/j.molmed.2012.04.009

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

377-84

issue

7

eissn

1471-4914

issn

1471-499X

pii

S1471-4914(12)00072-X

journal_volume

18

pub_type

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