Abstract：
:miRNAs are small, noncoding RNAs that not only regulate gene expression within cells, but might also constitute promising extracellular biomarkers for a variety of pathologies, including the progressive muscle-wasting disorder Duchenne Muscular Dystrophy (DMD). A set of muscle-enriched miRNAs, the myomiRs (miR-1, miR-133, and miR-206) are highly elevated in the serum of patients with DMD and in dystrophin-deficient animal models. Furthermore, circulating myomiRs might be used as pharmacodynamic biomarkers, given that their levels can be restored towards wild-type levels following exon skipping therapy in dystrophic mice. The relationship between muscle pathology and extracellular myomiR release is complex, and incompletely understood. Here, we discuss current progress leading towards the clinical utility of extracellular miRNAs as putative DMD biomarkers, and their possible contribution to muscle physiology.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Coenen-Stass AML,Wood MJA,Roberts TCdoi
10.1016/j.molmed.2017.09.002subject
Has Abstractpub_date
2017-11-01 00:00:00pages
989-1001issue
11eissn
1471-4914issn
1471-499Xpii
S1471-4914(17)30161-2journal_volume
23pub_type
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