Cytoplasmic nucleic acid sensors in antiviral immunity.

Abstract:

:The innate immune system uses pattern recognition receptors (PRRs) to sense invading microbes and initiate a rapid protective response. PRRs bind and are activated by structural motifs, such as nucleic acids or bacterial and fungal cell wall components, collectively known as pathogen-associated molecular patterns. PRRs that recognize pathogen-derived nucleic acids are present in vesicular compartments and in the cytosol of most cell types. Here, we review recent studies of these cytosolic sensors, focusing on the nature of the ligands for DNA-dependent activator of interferon (DAI)-regulatory factors, absent in melanoma 2 (AIM2), and the retinoic acid-inducible gene I-like helicase (RLH) family of receptors, the basis of ligand recognition and the signaling pathways triggered by the activation of these receptors. An increased understanding of these molecular aspects of innate immunity will guide the development of novel antiviral therapeutics.

journal_name

Trends Mol Med

authors

Ranjan P,Bowzard JB,Schwerzmann JW,Jeisy-Scott V,Fujita T,Sambhara S

doi

10.1016/j.molmed.2009.06.003

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

359-68

issue

8

eissn

1471-4914

issn

1471-499X

pii

S1471-4914(09)00116-6

journal_volume

15

pub_type

杂志文章,评审
  • Exhaled Molecular Fingerprinting in Diagnosis and Monitoring: Validating Volatile Promises.

    abstract::Medical diagnosis and phenotyping increasingly incorporate information from complex biological samples. This has promoted the development and clinical application of non-invasive metabolomics in exhaled air (breathomics). In respiratory medicine, expired volatile organic compounds (VOCs) are associated with inflammato...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2015.08.001

    authors: Boots AW,Bos LD,van der Schee MP,van Schooten FJ,Sterk PJ

    更新日期:2015-10-01 00:00:00

  • Transgenerational epigenetic inheritance requires a much deeper analysis.

    abstract::In his article, Szyf [1] has addressed the key challenges in and the controversies surrounding nongenetic inheritance. However, crucial findings that are important to counter two major criticisms held against transgenerational inheritance, especially in mammals--namely epigenetic memory survival across generations, an...

    journal_title:Trends in molecular medicine

    pub_type: 评论,信件

    doi:10.1016/j.molmed.2015.02.010

    authors: Sharma A

    更新日期:2015-05-01 00:00:00

  • Genomics and personalised whole-of-life healthcare.

    abstract::Genome sequencing has the potential for stratified cancer treatment and improved diagnostics for rare disorders. However, sequencing needs to be utilised in risk stratification on a population scale to deepen the impact on the health system by addressing common diseases, where individual genomic variants have variable...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2014.04.001

    authors: Bauer DC,Gaff C,Dinger ME,Caramins M,Buske FA,Fenech M,Hansen D,Cobiac L

    更新日期:2014-09-01 00:00:00

  • miRNAs in B Cell Development and Lymphomagenesis.

    abstract::B lymphocytes are essential for an efficient immune response against a variety of pathogens. A large fraction of hematologic malignancies is of B cell origin, suggesting that the development and activation of B cells need to be tightly regulated. In recent years, increasing evidence has emerged demonstrating that micr...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2017.06.001

    authors: Coffre M,Koralov SB

    更新日期:2017-08-01 00:00:00

  • Therapeutic Perspectives for Interferons and Plasmacytoid Dendritic Cells in Rheumatoid Arthritis.

    abstract::Rheumatoid arthritis (RA) is a multifactorial immune disease exhibiting diverse clinical responses to specific therapeutic agents. Such heterogeneity reflects variable activation of signaling pathways. Consequently, RA physiopathology has been linked to many immune cells and factors, with controversial observations fo...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2018.02.001

    authors: Nehmar R,Mariotte A,de Cauwer A,Sibilia J,Bahram S,Georgel P

    更新日期:2018-04-01 00:00:00

  • Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology.

    abstract::Microglia are the resident macrophages of the central nervous system (CNS). They have important physiological functions in maintaining tissue homeostasis but also contribute to CNS pathology. Microglia respond to changes in the microenvironment, and the resulting reactive phenotype can be very diverse, with both neuro...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2018.11.005

    authors: Voet S,Prinz M,van Loo G

    更新日期:2019-02-01 00:00:00

  • The role of innate immunity activation in house dust mite allergy.

    abstract::House dust mite (HDM) allergy is a frequent inflammatory disease found worldwide. Although allergen-specific CD4(+) Th2 cells orchestrate the HDM allergic response, notably through induction of IgE directed towards mite allergens, recent studies have demonstrated that innate immunity activation also plays a critical r...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2011.05.014

    authors: Jacquet A

    更新日期:2011-10-01 00:00:00

  • Novel Immunotherapeutic Avenues for Rheumatoid Arthritis.

    abstract::Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease. It leads to irreversible joint damage, physical handicap, and reduced life expectancy. The past two decades have seen considerable therapeutic advances with the development of biologic treatments to block proinflammatory cytokines or modulate...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2016.01.005

    authors: Semerano L,Minichiello E,Bessis N,Boissier MC

    更新日期:2016-03-01 00:00:00

  • Clinical applications of pathogen phylogenies.

    abstract::Innovative sequencing techniques now allow the routine access of whole genomes of pathogens, generating vast amounts of data. Phylogenetic trees are a common method for synthesizing this information. Unfortunately, these trees are often seen only as a visual support to guide researchers, thus neglecting the value of e...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2014.04.002

    authors: Hartfield M,Murall CL,Alizon S

    更新日期:2014-07-01 00:00:00

  • Tools for Bioimaging Pancreatic β Cells in Diabetes.

    abstract::When diabetes is diagnosed, the majority of insulin-secreting pancreatic β cells are already dysfunctional or destroyed. This β cell dysfunction/destruction usually takes place over many years, making timely detection and clinical intervention difficult. For this reason, there is immense interest in developing tools t...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2019.05.004

    authors: Kang NY,Soetedjo AAP,Amirruddin NS,Chang YT,Eriksson O,Teo AKK

    更新日期:2019-08-01 00:00:00

  • Inflammation meets oxidation: NF-kappaB as a mediator of initial lesion development in atherosclerosis.

    abstract::Transcription factor nuclear factor-kappaB (NF-kappaB) and its target genes are involved in the pathogenesis of atherosclerosis, in addition to many other diseases. Monocyte recruitment into subendothelial space is primarily mediated by NF-kappaB-dependent gene expression, and this event is a crucial milestone, becaus...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2003.10.007

    authors: Kutuk O,Basaga H

    更新日期:2003-12-01 00:00:00

  • Mitogen-activated protein kinases in male reproductive function.

    abstract::Recent studies have shown that male reproductive function is modulated via the mitogen-activated protein kinase (MAPK) cascade. The MAPK cascade is involved in numerous male reproductive processes, including spermatogenesis, sperm maturation and activation, capacitation and acrosome reaction, before fertilization of t...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2009.02.002

    authors: Li MW,Mruk DD,Cheng CY

    更新日期:2009-04-01 00:00:00

  • Stereocilia: the long and the short of it.

    abstract::Mutations in whirlin, a putative PDZ scaffold protein, have recently been shown to cause deafness and short cochlear hair cell stereocilia in whirler mice and recessive deafness (DFNB31) in humans. Through its PDZ domains, whirlin might organize a group of proteins into a functional complex required for stereocilia el...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章

    doi:10.1016/j.molmed.2003.09.008

    authors: Belyantseva IA,Labay V,Boger ET,Griffith AJ,Friedman TB

    更新日期:2003-11-01 00:00:00

  • Kaposi's sarcoma as a model for cancer immunotherapy.

    abstract::Physicians have, for over a century, attempted to harness the potential therapeutic power of the immune system to treat patients with cancer. The discovery that cancer regression can be achieved by immune rejection of tumour antigens theoretically allows the eradication of neoplastic cells without toxicity to normal t...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2004.02.006

    authors: Stebbing J,Bower M,Srivastava P

    更新日期:2004-04-01 00:00:00

  • Autophagy as a basis for the health-promoting effects of vitamin D.

    abstract::Autophagy is an evolutionarily conserved lysosomal self-digestion process essential for cellular homeostasis, differentiation and survival. As an adaptive response, it protects organisms against a wide range of pathologies, including cancer, infection, neurodegeneration, heart disease and ageing. Thus, compounds activ...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章

    doi:10.1016/j.molmed.2010.04.005

    authors: Høyer-Hansen M,Nordbrandt SP,Jäättelä M

    更新日期:2010-07-01 00:00:00

  • Preparing the Way: Exploiting Genomic Medicine to Stop Smoking.

    abstract::Clinical medicine of the future is poised to use an individual's genomic data to predict disease risk and guide clinical care. The treatment of cigarette smoking and tobacco use disorder represents a prime area for genomics implementation. The genes CHRNA5 and CYP2A6 are strong genomic contributors that alter the risk...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2017.12.001

    authors: Bierut LJ,Tyndale RF

    更新日期:2018-02-01 00:00:00

  • Protein kinase A as a therapeutic target for memory disorders: rationale and challenges.

    abstract::cAMP-dependent protein kinase A (PKA) signaling has a key role in memory processes and has been identified as a potential therapeutic target for memory disorders. The activation of PKA signaling is crucial for the consolidation of long-term memories dependent on the hippocampus and/or the amygdala, By contrast, initia...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2005.01.006

    authors: Arnsten AF,Ramos BP,Birnbaum SG,Taylor JR

    更新日期:2005-03-01 00:00:00

  • Senescent Cells Drive Frailty through Systemic Signals.

    abstract::Senescent cells drive ageing and the associated loss in health and lifespan. Whether this is mediated by systemic signalling remained unclear. Recently, Xu et al. [1] (Nat. Med. 2018;24:1246-1256) answered this question by injecting senescent cells into young mice and observing a long-lasting increase in frailty and m...

    journal_title:Trends in molecular medicine

    pub_type: 评论,杂志文章

    doi:10.1016/j.molmed.2018.09.003

    authors: Lehmann J,Baar MP,de Keizer PLJ

    更新日期:2018-11-01 00:00:00

  • Broadly Neutralizing Antibodies against HIV: Back to Blood.

    abstract::After years of continuous exposure to HIV envelope antigens, a minority of HIV-infected individuals develop a cognate polyclonal humoral response comprising very potent and extremely cross-reactive neutralizing antibodies [broadly neutralizing antibodies (bNAbs)]. Isolated bNAbs derived from memory B cell pools have b...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2019.01.007

    authors: Dashti A,DeVico AL,Lewis GK,Sajadi MM

    更新日期:2019-03-01 00:00:00

  • 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications.

    abstract::H(2)O(2) is a reactive oxygen species that has drawn much interest because of its role as a second messenger in receptor-mediated signaling. Mammalian 2-Cys peroxiredoxins have been shown to eliminate efficiently the H(2)O(2) generated in response to receptor stimulation. 2-Cys peroxiredoxins are members of a novel pe...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2005.10.006

    authors: Kang SW,Rhee SG,Chang TS,Jeong W,Choi MH

    更新日期:2005-12-01 00:00:00

  • Metabolic Pathways That Control Skin Homeostasis and Inflammation.

    abstract::Keratinocytes and skin immune cells are actively metabolizing nutrients present in their microenvironment. This is particularly important in common chronic inflammatory skin diseases such as psoriasis and atopic dermatitis, characterized by hyperproliferation of keratinocytes and expansion of inflammatory cells, thus ...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2020.04.004

    authors: Cibrian D,de la Fuente H,Sánchez-Madrid F

    更新日期:2020-11-01 00:00:00

  • Addressing Isolation in the Scientific Community.

    abstract::In STEM, and particularly in science, many early career researchers find themselves isolated and lacking guidance. There is an enormous need to connect early career scientists with experienced professionals outside their immediate work environment. A new initiative aims to create a supportive community to foster commu...

    journal_title:Trends in molecular medicine

    pub_type: 社论

    doi:10.1016/j.molmed.2019.08.007

    authors: Tomasello DL

    更新日期:2019-11-01 00:00:00

  • Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery.

    abstract::The efficacy of drugs administered by traditional routes is limited by numerous biological barriers that preclude reaching the intended site of action. Further, full body systemic exposure leads to dose-limiting, off-target side effects. Topical formulations may provide more efficacious drug and nucleic acid delivery ...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2020.12.001

    authors: Zierden HC,Josyula A,Shapiro RL,Hsueh HT,Hanes J,Ensign LM

    更新日期:2021-01-04 00:00:00

  • Immunotherapy: target the stroma to hit the tumor.

    abstract::For decades it has been assumed that T cells reject tumors essentially by direct killing. However, solid tumors are composed of malignant cells and a variety of different nonmalignant cells, referred to as tumor stroma. Stromal cells, such as endothelial cells, fibroblasts and inflammatory cells, often support tumor g...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2005.03.002

    authors: Kammertoens T,Schüler T,Blankenstein T

    更新日期:2005-05-01 00:00:00

  • Promoting brain remodeling to aid in stroke recovery.

    abstract::Endogenous brain repair after stroke involves a set of highly interactive processes, such as angiogenesis, neurogenesis, oligodendrogenesis, synaptogenesis, and axonal outgrowth, which together orchestrate neurological recovery. During the past several years, there have been advances in our understanding of miRNAs and...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2015.07.005

    authors: Zhang ZG,Chopp M

    更新日期:2015-09-01 00:00:00

  • Tau immunotherapy for Alzheimer's disease.

    abstract::Targeting pathological tau protein in Alzheimer's disease (AD) and related tauopathies has shown great potential in animal models. Given that tau lesions correlate better with the degree of dementia than do amyloid-β (Aβ) plaques, their clearance may be clinically more efficacious than removing Aβ when cognitive defic...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2015.03.003

    authors: Pedersen JT,Sigurdsson EM

    更新日期:2015-06-01 00:00:00

  • Hormonal regulation of placental nitric oxide and pathogenesis of pre-eclampsia.

    abstract::The placenta is central to foetal growth and development in mammalian pregnancy. Compromised placental function (as found in pre-eclampsia) often results in life-threatening situations for both mother and foetus. The nitric-oxide (NO) signalling cascade is important for placental function, in particular for the develo...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2006.03.003

    authors: Vatish M,Randeva HS,Grammatopoulos DK

    更新日期:2006-05-01 00:00:00

  • Molecular and immune toxicity of CoCr nanoparticles in MoM hip arthroplasty.

    abstract::Theoretical, desirable features of second-generation metal-on-metal (MoM) hip prostheses have led to their widespread use. However, the bearing surfaces, consisting of complex cobalt-chromium alloys, are subject to wear and the release of cobalt and chromium (CoCr) nanoparticles. These nanoparticles can reduce cellula...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2011.12.002

    authors: Gill HS,Grammatopoulos G,Adshead S,Tsialogiannis E,Tsiridis E

    更新日期:2012-03-01 00:00:00

  • Noncoding RNAs: Master Regulators of Inflammatory Signaling.

    abstract::Inflammatory signaling underlies many diseases, from arthritis to cancer. Our understanding of inflammation has thus far been limited to the world of proteins, because we are only just beginning to understand the role that noncoding RNAs (ncRNA) might play. It is now clear that ncRNA do not constitute transcriptional ...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2017.11.003

    authors: Chew CL,Conos SA,Unal B,Tergaonkar V

    更新日期:2018-01-01 00:00:00

  • Mixing the right hepatitis C inhibitor cocktail.

    abstract::Therapy for hepatitis C virus (HCV) infection is on the cusp of a new era. Until now, standard-of-care therapy has involved interferon (IFN) and ribavirin. With the first successful Phase III trials of specific targeted antiviral therapy for HCV (STAT-C) compounds, as well as three trials in progress giving the first ...

    journal_title:Trends in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.molmed.2010.10.005

    authors: Gelman MA,Glenn JS

    更新日期:2011-01-01 00:00:00