Abstract：
:Protective autoimmunity is the body's defense mechanism against destructive self-compounds such as those commonly associated with neurodegenerative disorders. Autoimmune disease and neurodegenerative disorders can thus be viewed as two extreme manifestations of the same process. Therefore, when designing therapy, it is important to avoid an approach that will cure the one by invoking the other. One way to stop, or at least slow down, the progression of neurodegeneration without risking development of an autoimmune disease is by boosting protective autoimmunity in a well-controlled way. Copolymer 1 (Cop-1), an approved drug for the treatment of multiple sclerosis, can be used as a treatment for autoimmune diseases and as a therapeutic vaccine for neurodegenerative diseases. We propose that the protective effect of Cop-1 vaccination is obtained through a well-controlled inflammatory reaction, and that the activity of Cop-1 in driving this reaction derives from its ability to serve as a 'universal antigen' by weakly activating a wide spectrum of self-reactive T cells.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Kipnis J,Schwartz Mdoi
10.1016/s1471-4914(02)02373-0keywords:
subject
Has Abstractpub_date
2002-07-01 00:00:00pages
319-23issue
7eissn
1471-4914issn
1471-499Xpii
S1471491402023730journal_volume
8pub_type
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