Abstract：
:Mechanisms underlying antipsychotic cardiometabolic adverse effects are incompletely understood. This hampers the identification of high-risk patients, low-risk antipsychotics and preventive/ameliorative treatments. Recent clinical, molecular and genetic data suggest that: (i) antipsychotic-naïve samples provide the greatest power for mechanistic studies; (ii) weight and metabolic effects can be discordant, pointing to overlapping and distinct mechanisms; (iii) antipsychotics affect satiety and energy homeostasis signaling; (iv) the specific peptides mediating these effects are unknown but probably overlap with those involved in idiopathic obesity; and (v) single nucleotide polymorphisms in genes encoding known neurotransmitter receptors and metabolic proteins are promising pharmacogenomic targets for countering adverse affects. However, sophisticated molecular studies and genome-wide association studies, ideally in antipsychotic-naïve/first episode samples, are needed to further advance the field.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Correll CU,Lencz T,Malhotra AKdoi
10.1016/j.molmed.2010.10.010subject
Has Abstractpub_date
2011-02-01 00:00:00pages
97-107issue
2eissn
1471-4914issn
1471-499Xpii
S1471-4914(10)00168-1journal_volume
17pub_type
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