Abstract：
:Invariant natural killer T (iNKT) cells are innate lymphocytes with unique specificity for glycolipid antigens and remarkable immunomodulatory properties. The role of costimulatory interactions in iNKT cell responses has recently come under scrutiny. Although iNKT cells and their prototype glycolipid agonist α-galactosylceramide (α-GalCer) have shown promise in several clinical trials conducted in patients with cancer or viral diseases, current iNKT cell-based therapies are far from effective. The concomitant targeting of T cell receptors (TCRs) and costimulatory molecules on iNKT cells represents an exciting new opportunity to optimize such therapeutic approaches. Here, we review recent advances in our understanding of iNKT cell costimulation and discuss potential treatment modalities based on the responsiveness of iNKT cells to disease-tailored glycolipids and select costimulatory ligands.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
van den Heuvel MJ,Garg N,Van Kaer L,Haeryfar SMdoi
10.1016/j.molmed.2010.10.007subject
Has Abstractpub_date
2011-02-01 00:00:00pages
65-77issue
2eissn
1471-4914issn
1471-499Xpii
S1471-4914(10)00161-9journal_volume
17pub_type
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