Abstract：
:Keratinocytes and skin immune cells are actively metabolizing nutrients present in their microenvironment. This is particularly important in common chronic inflammatory skin diseases such as psoriasis and atopic dermatitis, characterized by hyperproliferation of keratinocytes and expansion of inflammatory cells, thus suggesting increased cell nutritional requirements. Proliferating inflammatory cells and keratinocytes express high levels of glucose transporter (GLUT)1, l-type amino acid transporter (LAT)1, and cationic amino acid transporters (CATs). Main metabolic regulators such as hypoxia-inducible factor (HIF)-1α, MYC, and mechanistic target of rapamycin (mTOR) control immune cell activation, proliferation, and cytokine release. Here, we provide an updated perspective regarding the potential role of nutrient transporters and metabolic pathways that could be common to immune cells and keratinocytes, to control psoriasis and atopic dermatitis.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Cibrian D,de la Fuente H,Sánchez-Madrid Fdoi
10.1016/j.molmed.2020.04.004subject
Has Abstractpub_date
2020-11-01 00:00:00pages
975-986issue
11eissn
1471-4914issn
1471-499Xpii
S1471-4914(20)30106-4journal_volume
26pub_type
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