Chemical Strike against a Dominant-Inherited MUC1-Frameshifted Protein Associated with Progressive Kidney Disease.

abstract：:Medical diagnosis and phenotyping increasingly incorporate information from complex biological samples. This has promoted the development and clinical application of non-invasive metabolomics in exhaled air (breathomics). In respiratory medicine, expired volatile organic compounds (VOCs) are associated with inflammato...

journal_title：Trends in molecular medicine

authors： Boots AW,Bos LD,van der Schee MP,van Schooten FJ,Sterk PJ

更新日期：2015-10-01 00:00:00

abstract：:The Hedgehog (Hh) cascade controls cell proliferation, differentiation and patterning of tissues during embryogenesis but is largely suppressed in the adult. The Hh pathway can become reactivated in cancer. Here, we assimilate data from recent studies to understand how and when the Hh pathway is turned on to aid the n...

journal_title：Trends in molecular medicine

authors： Barakat MT,Humke EW,Scott MP

更新日期：2010-08-01 00:00:00

abstract：:Innate immunity is the first line of defense against invading pathogens. A family of Toll-like receptors (TLRs) acts as primary sensors that detect a wide variety of microbial components and elicit innate immune responses. All TLR signaling pathways culminate in activation of the transcription factor nuclear factor-ka...

journal_title：Trends in molecular medicine

authors： Kawai T,Akira S

更新日期：2007-11-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is the most common potentially lethal monogenic disorder, with more than 12 million cases worldwide. The two causative genes for ADPKD, PKD1 and PKD2, encode protein products polycystin-1 (PC1) and polycystin-2 (PC2 or TRPP2), respectively. Recent data have shed lig...

journal_title：Trends in molecular medicine

authors： Fedeles SV,Gallagher AR,Somlo S

更新日期：2014-05-01 00:00:00

abstract：:cAMP-dependent protein kinase A (PKA) signaling has a key role in memory processes and has been identified as a potential therapeutic target for memory disorders. The activation of PKA signaling is crucial for the consolidation of long-term memories dependent on the hippocampus and/or the amygdala, By contrast, initia...

journal_title：Trends in molecular medicine

authors： Arnsten AF,Ramos BP,Birnbaum SG,Taylor JR

更新日期：2005-03-01 00:00:00

abstract：:A recent study introduced the existence of an 'immune clock' in pregnancy; during the course of gestation, peripheral blood cells from pregnant women were analyzed by mass cytometry using a single-cell signaling-based elastic net algorithm. The insights will undoubtedly promote the testing of such a clock - possibly i...

journal_title：Trends in molecular medicine

authors： Diemert A,Arck PC

更新日期：2018-01-01 00:00:00

abstract：:Salmonella Typhimurium, engineered to express flagellin B, recently demonstrated unprecedented tumor control through a TLR-dependent mechanism. Here, we review new observations that support the potential of utilizing modified bacteria to enhance antitumor immunity. We also discuss the implications of these findings fo...

journal_title：Trends in molecular medicine

authors： Binder DC,Wainwright DA

更新日期：2017-07-01 00:00:00

abstract：:During fertilization, the spermatozoon penetrates through the cumulus cells and the zona pellucida that surrounds the oocyte, before it binds and fuses with the oocyte plasma membrane to induce activation. In vitro fertilization (IVF) studies performed in non-human mammals have contributed extensive knowledge regardin...

journal_title：Trends in molecular medicine

authors： Ben-Yosef D,Shalgi R

更新日期：2001-04-01 00:00:00

abstract：:During the past decade, successful gene therapies for immunodeficiencies were finally brought to the clinic. This was accomplished through new gene therapy vectors and improved procedures for genetic modification of autologous hematopoietic stem cells. For HIV, autologous hematopoietic stem cell (HSC) gene therapy wit...

journal_title：Trends in molecular medicine

authors： Abou-El-Enein M,Bauer G,Reinke P,Renner M,Schneider CK

更新日期：2014-11-01 00:00:00

abstract：:Cyclic dipeptides (CDPs) are a group of hormone-like molecules that are evolutionarily conserved from bacteria to humans. In bacteria, CDPs are used in quorum sensing (QS) to communicate information about population size and to regulate a behavioural switch from symbiosis with their host to virulence. In mammals, CDPs...

journal_title：Trends in molecular medicine

authors： Bellezza I,Peirce MJ,Minelli A

更新日期：2014-10-01 00:00:00

abstract：:Sphingosine kinase 1 (SphK1) knockout mice are protected against pulmonary hypertension and expression levels of the enzyme are increased in the lungs of pulmonary arterial hypertensive (PAH) patients. Moreover, sphingosine 1-phosphate can promote vascular remodeling/vasoconstriction in rodent and human pulmonary arte...

journal_title：Trends in molecular medicine

authors： Pyne NJ,Pyne S

更新日期：2017-09-01 00:00:00

abstract：:Epigenome-wide association studies (EWASs) provide a systematic approach to uncovering epigenetic variants underlying common diseases. Discoveries have shed light on novel molecular mechanisms of disease and enabled the application of epigenetic variants as biomarkers. Here, we highlight the recent advances in this em...

journal_title：Trends in molecular medicine

authors： Paul DS,Beck S

更新日期：2014-10-01 00:00:00

abstract：:Despite advances in treatment for glioblastoma multiforme (GBM), patient prognosis remains poor. Although there is growing evidence that molecular targeting could translate into better survival for GBM, current clinical data show limited impact on survival. Recent progress in GBM genomics implicate several activated p...

journal_title：Trends in molecular medicine

authors： Bai RY,Staedtke V,Riggins GJ

更新日期：2011-06-01 00:00:00

abstract：:In the coming years, molecular diagnostics will continue to be of critical importance to public health worldwide. It will facilitate the detection and characterization of disease, as well as monitoring of the drug response, and will assist in the identification of genetic modifiers and disease susceptibility. A wide r...

journal_title：Trends in molecular medicine

authors： Fortina P,Surrey S,Kricka LJ

更新日期：2002-06-01 00:00:00

abstract：:Hypoxia-inducible factor 1 (HIF-1) controls oxygen delivery (via angiogenesis) and metabolic adaptation to hypoxia (via glycolysis). HIF-1 consists of a constitutively expressed HIF-1 beta subunit and an oxygen- and growth-factor-regulated HIF-1 alpha subunit. In xenografts, tumor growth and angiogenesis are correlate...

journal_title：Trends in molecular medicine

authors： Semenza GL

更新日期：2002-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are currently being tested in clinical trials for the treatment of various diseases owing to the ease of generating and expanding these cells, the ability to differentiate them into various specialized mesenchymal tissue types and their immunosuppressive properties. However, their immunom...

journal_title：Trends in molecular medicine

authors： Gebler A,Zabel O,Seliger B

更新日期：2012-02-01 00:00:00

abstract：:Alterations in histone lysine methylation and other epigenetic regulators of gene expression contribute to changes in brain transcriptomes in mood and psychosis spectrum disorders, including depression and schizophrenia. Genetic association studies and animal models implicate multiple lysine methyltransferases and dem...

journal_title：Trends in molecular medicine

authors： Peter CJ,Akbarian S

更新日期：2011-07-01 00:00:00

abstract：:It is now well recognized that cells traffic in both directions between fetus and mother during pregnancy. Moreover, fetal cells have been found to persist for years, probably for a lifetime, in the circulation of healthy women. Harboring of cells from another individual at low levels is called microchimerism. Women h...

journal_title：Trends in molecular medicine

authors： Nelson JL

更新日期：2002-03-01 00:00:00

abstract：:The programmed death 1 (PD-1) receptor and its ligands programmed death ligand 1 (PD-L1) and PD-L2, members of the CD28 and B7 families, play critical roles in T cell coinhibition and exhaustion. Overexpression of PD-L1 and PD-1 on tumor cells and tumor-infiltrating lymphocytes, respectively, correlates with poor dise...

journal_title：Trends in molecular medicine

authors： Ohaegbulam KC,Assal A,Lazar-Molnar E,Yao Y,Zang X

更新日期：2015-01-01 00:00:00

abstract：:While the hippocampus has long been recognized as a brain structure specialized in mapping 'space' in rodents, human studies and now recent data from rodents have shown that its function extends well beyond spatial coding. Recently, an overlooked area of the hippocampus, CA2, has emerged as a critical region for socia...

journal_title：Trends in molecular medicine

authors： Chevaleyre V,Piskorowski RA

更新日期：2016-08-01 00:00:00

abstract：:Chronic hepatitis C is a leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. Although current treatment options are limited, progress in understanding the molecular virology of hepatitis C has led to the identification of novel antiviral targets. Moreover, in vitro and in vivo model systems have b...

journal_title：Trends in molecular medicine

authors： Moradpour D,Brass V,Gosert R,Wölk B,Blum HE

更新日期：2002-10-01 00:00:00

abstract：:Accumulating evidence has revealed that immunogenic cell death triggered by particular chemotherapeutic agents plays a critical role in harnessing antitumor immunity to clinical responses. However, negative regulatory pathways exist which suppress the induction of effective immune responses by a broad spectrum of anti...

journal_title：Trends in molecular medicine

authors： Jinushi M,Yagita H,Yoshiyama H,Tahara H

更新日期：2013-09-01 00:00:00

abstract：:Adult skeletal muscle has remarkable regenerative potential, which is mainly attributable to a small population of undifferentiated skeletal muscle precursors called satellite cells. These cells reside underneath the basal lamina of skeletal myofibers and can be activated to proliferate, differentiate and fuse to form...

journal_title：Trends in molecular medicine

authors： Sherwood RI,Wagers AJ

更新日期：2006-05-01 00:00:00

abstract：:BAX is a formidable BCL-2 family protein that executes cellular suicide in response to physiologic and pathologic stress. A new article in Nature Chemical Biology (Garner et al.https://doi.org/10.1038/s41589-018-0223-0) reports small molecules that inhibit the conformational activation of BAX, informing a pharmacologi...

journal_title：Trends in molecular medicine

authors： Walensky LD

更新日期：2019-04-01 00:00:00

abstract：:Mounting in vitro and in vivo data suggest that the endocannabinoids anandamide and 2-arachidonoyl glycerol, as well as some plant and synthetic cannabinoids, have neuroprotective effects following brain injury. Cannabinoid receptor agonists inhibit glutamatergic synaptic transmission and reduce the production of tumo...

journal_title：Trends in molecular medicine

authors： Mechoulam R,Panikashvili D,Shohami E

更新日期：2002-02-01 00:00:00

abstract：:Caspase-mediated apoptosis is a major hindrance to tumour growth and metastasis. Accordingly, defects in signalling pathways leading to the activation of caspases are common in tumours. Moreover, many tumour cells can unexpectedly survive the activation of caspases. As a result, caspase-independent cell death programm...

journal_title：Trends in molecular medicine

authors： Mathiasen IS,Jäättelä M

更新日期：2002-05-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 and PKD2, encoding polycystin-1 and polycystin-2, respectively. Optimizing the folding environment for polycystin-1 missense mutations may have a critical effect on the progression of ADPKD in animal models and could potentially lead t...

journal_title：Trends in molecular medicine

authors： Krappitz M,Gallagher AR,Fedeles S

更新日期：2016-12-01 00:00:00

abstract：:Wound repair is a highly regulated process that requires the interaction of various cell types. It has been shown that cancers use the mechanisms of wound healing to promote their own growth. Therefore, it is of importance to identify common regulators of wound repair and tumor formation and to unravel their functions...

journal_title：Trends in molecular medicine

authors： Cangkrama M,Wietecha M,Werner S

更新日期：2020-12-01 00:00:00

abstract：:DNA vaccination is currently being explored as a potential strategy for combatting cancer. However, tumor antigens are often weak and the immune system of patients may be compromised. For B-cell tumors, immunoglobulin idiotypic antigens provide defined targets but are poorly immunogenic. Fusion of a sequence derived f...

journal_title：Trends in molecular medicine

authors： Zhu D,Rice J,Savelyeva N,Stevenson FK

更新日期：2001-12-01 00:00:00

abstract：:House dust mite (HDM) allergy is a frequent inflammatory disease found worldwide. Although allergen-specific CD4(+) Th2 cells orchestrate the HDM allergic response, notably through induction of IgE directed towards mite allergens, recent studies have demonstrated that innate immunity activation also plays a critical r...

journal_title：Trends in molecular medicine

authors： Jacquet A

更新日期：2011-10-01 00:00:00