Abstract：
:Innate immunity is the first line of defense against invading pathogens. A family of Toll-like receptors (TLRs) acts as primary sensors that detect a wide variety of microbial components and elicit innate immune responses. All TLR signaling pathways culminate in activation of the transcription factor nuclear factor-kappaB (NF-kappaB), which controls the expression of an array of inflammatory cytokine genes. NF-kappaB activation requires the phosphorylation and degradation of inhibitory kappaB (IkappaB) proteins, which is triggered by two kinases, IkappaB kinase alpha (IKKalpha) and IKKbeta. In addition, several TLRs activate alternative pathways involving the IKK-related kinases TBK1 [TRAF family member-associated NF-kappaB activator (TANK) binding kinase-1] and IKKi, which elicit antiviral innate immune responses. Here, we review recent progress in our understanding of the role of NF-kappaB in TLR signaling pathways and discuss potential implications for molecular medicine.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Kawai T,Akira Sdoi
10.1016/j.molmed.2007.09.002subject
Has Abstractpub_date
2007-11-01 00:00:00pages
460-9issue
11eissn
1471-4914issn
1471-499Xpii
S1471-4914(07)00184-0journal_volume
13pub_type
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