Abstract:
:Caspase-mediated apoptosis is a major hindrance to tumour growth and metastasis. Accordingly, defects in signalling pathways leading to the activation of caspases are common in tumours. Moreover, many tumour cells can unexpectedly survive the activation of caspases. As a result, caspase-independent cell death programmes are gaining increasing interest among cancer researchers. The heterogeneity of cancer cells with respect to their sensitivity to various death stimuli further emphasizes the need for additional death pathways in the therapeutic control of cell death. An understanding of the molecular control of alternative death pathways is beginning to emerge, being comparable with that of the molecular anatomy of apoptosis at the time of the discovery of caspases less than a decade ago. Here, newly discovered triggers and molecular regulators of alternative cell death programmes are reviewed and their potential in future cancer therapy is discussed.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Mathiasen IS,Jäättelä Mdoi
10.1016/s1471-4914(02)02328-6keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
212-20issue
5eissn
1471-4914issn
1471-499Xpii
S1471491402023286journal_volume
8pub_type
杂志文章,评审abstract::Natural killer (NK) cells are the most responsive immune cells to exercise, displaying an acute mobilization to the circulation during physical exertion. Recently, exercise-dependent mobilization of NK cells was found to play a central role in exercise-mediated protection against cancer. Here, we review the link betwe...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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doi:10.1016/j.molmed.2011.05.014
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journal_title:Trends in molecular medicine
pub_type: 评论,杂志文章
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doi:10.1016/j.molmed.2019.10.004
更新日期:2020-02-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 社论
doi:10.1016/j.molmed.2019.08.007
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journal_title:Trends in molecular medicine
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doi:10.1016/j.molmed.2004.06.009
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journal_title:Trends in molecular medicine
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doi:10.1016/j.molmed.2006.08.004
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pub_type: 评论,信件
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2005.10.006
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doi:10.1016/j.molmed.2014.07.002
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abstract::cAMP-dependent protein kinase A (PKA) signaling has a key role in memory processes and has been identified as a potential therapeutic target for memory disorders. The activation of PKA signaling is crucial for the consolidation of long-term memories dependent on the hippocampus and/or the amygdala, By contrast, initia...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2005.01.006
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abstract::The past few years have seen the identification of PTPN22 and the confirmation of CTLA-4 as common autoimmune disease genes. Together with MHC and INS, these developments have increased the collection of confirmed susceptibility loci for autoimmunity. In this article, the latest developments related to these genes and...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2005.12.005
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journal_title:Trends in molecular medicine
pub_type: 评论,杂志文章
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/s1471-4914(01)02026-3
更新日期:2001-07-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2007.05.003
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2004.11.001
更新日期:2005-01-01 00:00:00