Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health.

Abstract:

:Environmental effects on the materno-foetal interaction determine birth outcomes that predict health over the lifespan. Thus, maternal undernutrition or stress associate with low birth weight, leading to an increased risk of metabolic and cardiovascular illness in the offspring. We argue that these effects are, in part, mediated by direct and indirect effects on the hypothalamic-pituitary-adrenal (HPA) axis such that (i) the effect of maternal adversity on foetal growth is mediated by adrenal glucocorticoids and (ii) environmental adversity alters maternal physiology and behaviour, which then programs HPA activity in the offspring.

journal_name

Trends Mol Med

authors

Meaney MJ,Szyf M,Seckl JR

doi

10.1016/j.molmed.2007.05.003

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

269-77

issue

7

eissn

1471-4914

issn

1471-499X

pii

S1471-4914(07)00087-1

journal_volume

13

pub_type

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