Abstract：
:House dust mite (HDM) allergy is a frequent inflammatory disease found worldwide. Although allergen-specific CD4(+) Th2 cells orchestrate the HDM allergic response, notably through induction of IgE directed towards mite allergens, recent studies have demonstrated that innate immunity activation also plays a critical role in HDM-induced allergy pathogenesis. HDM allergens can not only be considered proteins that induce adaptive Th2-biased responses in susceptible subjects but also as strong activators of innate immune cells, including skin keratinocytes and airway epithelial cells. The contribution of microbial adjuvant factors, derived from HDM carriers or the environment, is also essential in such cell stimulation. This review highlights how HDM allergens, together with microbial compounds, promote allergic responses through pattern recognition receptor-dependent pathways.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Jacquet Adoi
10.1016/j.molmed.2011.05.014subject
Has Abstractpub_date
2011-10-01 00:00:00pages
604-11issue
10eissn
1471-4914issn
1471-499Xpii
S1471-4914(11)00101-8journal_volume
17pub_type
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