Abstract：
:Human skin responds to numerous neurohormones, neuropeptides, and neurotransmitters that reach it via the vasculature or skin nerves, and/or are generated intracutaneously, thus acting in a para- and autocrine manner. This review focuses on how neurohormones impact on human skin physiology and pathology. We highlight basic concepts, major open questions, and translational research perspectives in cutaneous neuroendocrinology and argue that greater emphasis on neuroendocrine human skin research will foster the development of novel dermatological therapies. Furthermore, human skin and its appendages can be used as highly accessible and clinically relevant model systems for probing nonclassical, ancestral neurohormone functions. This calls for close interdisciplinary collaboration between dermatologists, skin biologists, neuroendocrinologists, and neuropharmacologists.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Ramot Y,Böhm M,Paus Rdoi
10.1016/j.molmed.2020.09.002subject
Has Abstractpub_date
2021-01-01 00:00:00pages
60-74issue
1eissn
1471-4914issn
1471-499Xpii
S1471-4914(20)30219-7journal_volume
27pub_type
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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