Abstract：
:Medical diagnosis and phenotyping increasingly incorporate information from complex biological samples. This has promoted the development and clinical application of non-invasive metabolomics in exhaled air (breathomics). In respiratory medicine, expired volatile organic compounds (VOCs) are associated with inflammatory, oxidative, microbial, and neoplastic processes. After recent proof of concept studies demonstrating moderate to good diagnostic accuracies, the latest efforts in breathomics are focused on optimization of sensor technologies and analytical algorithms, as well as on independent validation of clinical classification and prediction. Current research strategies are revealing the underlying pathophysiological pathways as well as clinically-acceptable levels of diagnostic accuracy. Implementing recent guidelines on validating molecular signatures in medicine will enhance the clinical potential of breathomics and the development of point-of-care technologies.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Boots AW,Bos LD,van der Schee MP,van Schooten FJ,Sterk PJdoi
10.1016/j.molmed.2015.08.001subject
Has Abstractpub_date
2015-10-01 00:00:00pages
633-644issue
10eissn
1471-4914issn
1471-499Xpii
S1471-4914(15)00157-4journal_volume
21pub_type
杂志文章,评审abstract：:Recent whole exome sequencing studies in humans have provided novel insight into the importance of the ephrinB2-EphB4-RASA1 signaling axis in cerebrovascular development, corroborating and extending previous work in model systems. Here, we aim to review the human cerebrovascular phenotypes associated with ephrinB2-Eph...
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