Abstract：
:Human natural killer (NK) and gamma delta (gammadelta) T cells are potent effectors involved in the destruction of abnormal cells. Accumulating clinical and experimental data point towards a key role for NK cells and gammadelta T cells in the control of most, if not all, haematological malignancies. This review focuses on the alterations in these effector cells found in patients with haematological malignancies, which might explain an escape from innate immune surveillance. We discuss new anti-cancer drugs that target these effector cells indirectly or directly. Finally, we review future strategies that offer the possibility of enhancing the effector functions of NK and gammadelta T cells against haematological malignancies.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Rey J,Veuillen C,Vey N,Bouabdallah R,Olive Ddoi
10.1016/j.molmed.2009.04.005subject
Has Abstractpub_date
2009-06-01 00:00:00pages
275-84issue
6eissn
1471-4914issn
1471-499Xpii
S1471-4914(09)00085-9journal_volume
15pub_type
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
pub_type： 评论,杂志文章
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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journal_title：Trends in molecular medicine
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pub_type： 杂志文章,评审
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journal_title：Trends in molecular medicine
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