Abstract：
:When diabetes is diagnosed, the majority of insulin-secreting pancreatic β cells are already dysfunctional or destroyed. This β cell dysfunction/destruction usually takes place over many years, making timely detection and clinical intervention difficult. For this reason, there is immense interest in developing tools to bioimage β cell mass and/or function noninvasively to facilitate early diagnosis of diabetes as well as to assist the development of novel antidiabetic therapies. Recent years have brought significant progress in β cell imaging that is now inching towards clinical applicability. We explore here the need to bioimage human β cells noninvasively in various types of diabetes, and we discuss current and emerging tools for bioimaging β cells. Further developments in this field are expected to facilitate β cell imaging in diabetes.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Kang NY,Soetedjo AAP,Amirruddin NS,Chang YT,Eriksson O,Teo AKKdoi
10.1016/j.molmed.2019.05.004subject
Has Abstractpub_date
2019-08-01 00:00:00pages
708-722issue
8eissn
1471-4914issn
1471-499Xpii
S1471-4914(19)30106-6journal_volume
25pub_type
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