Abstract:
:Induction of pathogen-specific binding antibodies has long been considered a signature of protective immunity following vaccination and infection. The humoral immune response is a complex network of antibodies that target different specificities and drive different functions, collectively acting to limit and clear infection either directly, via pathogen neutralization, or indirectly, via pathogen clearance by the innate immune system. Emerging data suggest that not all antibody responses are equal, and qualitative features of antibodies may be key to defining protective immune profiles. Here, we review the most recent advances in our understanding of protective functional antibody responses in natural infection, vaccination, and monoclonal antibody therapeutics. Moreover, we highlight opportunities to augment or modulate antibody-mediated protection through enhancement of antibody functionality.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Gunn BM,Alter Gdoi
10.1016/j.molmed.2016.09.002subject
Has Abstractpub_date
2016-11-01 00:00:00pages
969-982issue
11eissn
1471-4914issn
1471-499Xpii
S1471-4914(16)30117-4journal_volume
22pub_type
杂志文章,评审abstract::Serotonin is an important neurohormonal factor that has been implicated in cardiovascular function. It can regulate vascular tone, act directly on cardiomyocytes and stimulate chemosensitive nerves in the heart. Cardiovascular dysfunction is observed when serotonin signaling is altered or when variation in serotonin c...
journal_title:Trends in molecular medicine
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abstract::Despite advances in treatment for glioblastoma multiforme (GBM), patient prognosis remains poor. Although there is growing evidence that molecular targeting could translate into better survival for GBM, current clinical data show limited impact on survival. Recent progress in GBM genomics implicate several activated p...
journal_title:Trends in molecular medicine
pub_type: 临床试验,杂志文章,评审
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abstract::Migraine is a complex, disabling disorder of the brain that manifests itself as attacks of often severe, throbbing head pain with sensory sensitivity to light, sound and head movement. There is a clear familial tendency to migraine, which has been well defined in a rare autosomal dominant form of familial hemiplegic m...
journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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abstract::Salmonella Typhimurium, engineered to express flagellin B, recently demonstrated unprecedented tumor control through a TLR-dependent mechanism. Here, we review new observations that support the potential of utilizing modified bacteria to enhance antitumor immunity. We also discuss the implications of these findings fo...
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journal_title:Trends in molecular medicine
pub_type: 杂志文章
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Trends in molecular medicine
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更新日期:2001-12-01 00:00:00
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2017.01.002
更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2021-01-08 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2008.11.003
更新日期:2009-01-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2015.03.003
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/s1471-4914(02)02328-6
更新日期:2002-05-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2006.03.002
更新日期:2006-05-01 00:00:00
abstract::To prevent duplication or loss of genomic regions during DNA replication, it is essential that the entire genome is copied precisely once every S phase. Cells achieve this by mutually exclusive regulation of origin firing and licensing. A crucial protein that is involved in origin licensing is chromatin licensing and ...
journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2006.08.004
更新日期:2006-10-01 00:00:00
abstract::CD4(+) T cells occupy a central role in the induction and regulation of adaptive immune responses. Activated CD4(+) T helper (Th) cells exert immediate effector functions by producing cytokines and chemokines, providing help for the induction of CD8(+) cytotoxic T lymphocyte responses and memory, and providing help fo...
journal_title:Trends in molecular medicine
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更新日期:2010-10-01 00:00:00
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journal_title:Trends in molecular medicine
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doi:10.1016/j.molmed.2016.06.007
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journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2005.07.006
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journal_title:Trends in molecular medicine
pub_type: 评论,信件
doi:10.1016/j.molmed.2015.02.010
更新日期:2015-05-01 00:00:00
abstract::The placenta is central to foetal growth and development in mammalian pregnancy. Compromised placental function (as found in pre-eclampsia) often results in life-threatening situations for both mother and foetus. The nitric-oxide (NO) signalling cascade is important for placental function, in particular for the develo...
journal_title:Trends in molecular medicine
pub_type: 杂志文章,评审
doi:10.1016/j.molmed.2006.03.003
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journal_title:Trends in molecular medicine
pub_type: 评论,杂志文章
doi:10.1016/j.molmed.2016.02.009
更新日期:2016-04-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2007.05.003
更新日期:2007-07-01 00:00:00
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journal_title:Trends in molecular medicine
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更新日期:2001-07-01 00:00:00
abstract::In the coming years, molecular diagnostics will continue to be of critical importance to public health worldwide. It will facilitate the detection and characterization of disease, as well as monitoring of the drug response, and will assist in the identification of genetic modifiers and disease susceptibility. A wide r...
journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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doi:10.1016/j.molmed.2009.06.007
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journal_title:Trends in molecular medicine
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doi:10.1016/j.molmed.2019.09.001
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