Abstract:
:The placenta is central to foetal growth and development in mammalian pregnancy. Compromised placental function (as found in pre-eclampsia) often results in life-threatening situations for both mother and foetus. The nitric-oxide (NO) signalling cascade is important for placental function, in particular for the development of the vascular network and for maintaining vascular tone. This pathway seems to be regulated by multiple hormonal signals. Emerging evidence suggests that pathogenic mechanisms that are involved in abnormal placental function target specific molecules, such as hormone receptors, that regulate NO release and have subsequent dramatic consequences. Here, we discuss the current knowledge of NO function in the placenta, its hormonal regulation in normal pregnancy and in the pathophysiology of pre-eclampsia, its potential pathogenic mechanisms and possible use as a therapeutic target.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Vatish M,Randeva HS,Grammatopoulos DKdoi
10.1016/j.molmed.2006.03.003subject
Has Abstractpub_date
2006-05-01 00:00:00pages
223-33issue
5eissn
1471-4914issn
1471-499Xpii
S1471-4914(06)00061-Xjournal_volume
12pub_type
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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doi:10.1016/s1471-4914(03)00005-4
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
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journal_title:Trends in molecular medicine
pub_type: 杂志文章
doi:10.1016/j.molmed.2014.07.002
更新日期:2014-10-01 00:00:00
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journal_title:Trends in molecular medicine
pub_type: 评论,杂志文章
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